LSME1_MOUSE
ID LSME1_MOUSE Reviewed; 128 AA.
AC Q3UQS2; Q3UZ75;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Leucine-rich single-pass membrane protein 1;
GN Name=Lsmem1; Synonyms=Gm889;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Heart, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UQS2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UQS2-2; Sequence=VSP_029105;
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DR EMBL; AK134025; BAE21983.1; -; mRNA.
DR EMBL; AK142184; BAE24967.1; -; mRNA.
DR CCDS; CCDS25892.1; -. [Q3UQS2-1]
DR RefSeq; NP_001028609.1; NM_001033437.2. [Q3UQS2-1]
DR AlphaFoldDB; Q3UQS2; -.
DR SMR; Q3UQS2; -.
DR STRING; 10090.ENSMUSP00000093434; -.
DR iPTMnet; Q3UQS2; -.
DR PhosphoSitePlus; Q3UQS2; -.
DR PaxDb; Q3UQS2; -.
DR PRIDE; Q3UQS2; -.
DR ProteomicsDB; 290180; -. [Q3UQS2-1]
DR ProteomicsDB; 290181; -. [Q3UQS2-2]
DR Antibodypedia; 2673; 73 antibodies from 12 providers.
DR Ensembl; ENSMUST00000095760; ENSMUSP00000093434; ENSMUSG00000071342. [Q3UQS2-1]
DR Ensembl; ENSMUST00000220951; ENSMUSP00000152529; ENSMUSG00000071342. [Q3UQS2-2]
DR GeneID; 380755; -.
DR KEGG; mmu:380755; -.
DR UCSC; uc007nkx.1; mouse. [Q3UQS2-1]
DR UCSC; uc011ylp.1; mouse. [Q3UQS2-2]
DR CTD; 286006; -.
DR MGI; MGI:2685735; Lsmem1.
DR VEuPathDB; HostDB:ENSMUSG00000071342; -.
DR eggNOG; ENOG502SU77; Eukaryota.
DR GeneTree; ENSGT00390000010292; -.
DR HOGENOM; CLU_159418_0_0_1; -.
DR InParanoid; Q3UQS2; -.
DR OMA; CPAESQH; -.
DR PhylomeDB; Q3UQS2; -.
DR TreeFam; TF336352; -.
DR BioGRID-ORCS; 380755; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Lsmem1; mouse.
DR PRO; PR:Q3UQS2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3UQS2; protein.
DR Bgee; ENSMUSG00000071342; Expressed in quadriceps femoris and 27 other tissues.
DR ExpressionAtlas; Q3UQS2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028099; DUF4577.
DR PANTHER; PTHR36475; PTHR36475; 1.
DR Pfam; PF15145; DUF4577; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..128
FT /note="Leucine-rich single-pass membrane protein 1"
FT /id="PRO_0000309273"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 90..111
FT /evidence="ECO:0000255"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 43..86
FT /note="SLEDKIPNAGTAPGNGRRGLFFVGLLLVLTVSLALVFFAIFLII -> F
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029105"
SQ SEQUENCE 128 AA; 14186 MW; CA2AA4EEEA94B012 CRC64;
MTHSSQDAGS HGIQEEGRLY VVDSINDLNK LSLCPMESQH LFSLEDKIPN AGTAPGNGRR
GLFFVGLLLV LTVSLALVFF AIFLIIQTGN QMEDVSRRLT AEGKDIDDLK KINNMIVKRL
NQLDSEQN
