LSME2_HUMAN
ID LSME2_HUMAN Reviewed; 164 AA.
AC Q8N112;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Leucine-rich single-pass membrane protein 2;
GN Name=LSMEM2; Synonyms=C3orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N112; P21854: CD72; NbExp=3; IntAct=EBI-10264855, EBI-307924;
CC Q8N112; O95471: CLDN7; NbExp=3; IntAct=EBI-10264855, EBI-740744;
CC Q8N112; Q2HXU8-2: CLEC12B; NbExp=3; IntAct=EBI-10264855, EBI-12811991;
CC Q8N112; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-10264855, EBI-12019274;
CC Q8N112; Q07325: CXCL9; NbExp=3; IntAct=EBI-10264855, EBI-3911467;
CC Q8N112; P54849: EMP1; NbExp=6; IntAct=EBI-10264855, EBI-4319440;
CC Q8N112; Q96F15: GIMAP5; NbExp=6; IntAct=EBI-10264855, EBI-6166686;
CC Q8N112; P26715: KLRC1; NbExp=3; IntAct=EBI-10264855, EBI-9018187;
CC Q8N112; Q8N8F7: LSMEM1; NbExp=8; IntAct=EBI-10264855, EBI-10200825;
CC Q8N112; P26678: PLN; NbExp=3; IntAct=EBI-10264855, EBI-692836;
CC Q8N112; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-10264855, EBI-8652744;
CC Q8N112; P11686: SFTPC; NbExp=3; IntAct=EBI-10264855, EBI-10197617;
CC Q8N112; O43765: SGTA; NbExp=3; IntAct=EBI-10264855, EBI-347996;
CC Q8N112; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-10264855, EBI-741850;
CC Q8N112; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-10264855, EBI-17498703;
CC Q8N112; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10264855, EBI-742688;
CC Q8N112; O15400: STX7; NbExp=3; IntAct=EBI-10264855, EBI-3221827;
CC Q8N112; Q96AN5: TMEM143; NbExp=3; IntAct=EBI-10264855, EBI-13342951;
CC Q8N112; A2RU14: TMEM218; NbExp=5; IntAct=EBI-10264855, EBI-10173151;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK095927; BAC04652.1; -; mRNA.
DR EMBL; U73167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028000; AAH28000.1; -; mRNA.
DR CCDS; CCDS2814.1; -.
DR RefSeq; NP_001291314.1; NM_001304385.1.
DR RefSeq; NP_694947.1; NM_153215.2.
DR AlphaFoldDB; Q8N112; -.
DR SMR; Q8N112; -.
DR BioGRID; 126313; 52.
DR IntAct; Q8N112; 19.
DR STRING; 9606.ENSP00000315081; -.
DR BioMuta; LSMEM2; -.
DR DMDM; 74728479; -.
DR PaxDb; Q8N112; -.
DR PeptideAtlas; Q8N112; -.
DR PRIDE; Q8N112; -.
DR Antibodypedia; 64735; 29 antibodies from 6 providers.
DR DNASU; 132228; -.
DR Ensembl; ENST00000316436.4; ENSP00000315081.3; ENSG00000179564.4.
DR GeneID; 132228; -.
DR KEGG; hsa:132228; -.
DR MANE-Select; ENST00000316436.4; ENSP00000315081.3; NM_153215.3; NP_694947.1.
DR UCSC; uc003cyz.4; human.
DR CTD; 132228; -.
DR DisGeNET; 132228; -.
DR GeneCards; LSMEM2; -.
DR HGNC; HGNC:26781; LSMEM2.
DR HPA; ENSG00000179564; Tissue enhanced (heart muscle, skeletal muscle).
DR neXtProt; NX_Q8N112; -.
DR PharmGKB; PA143485322; -.
DR VEuPathDB; HostDB:ENSG00000179564; -.
DR eggNOG; ENOG502SABZ; Eukaryota.
DR GeneTree; ENSGT00390000000577; -.
DR HOGENOM; CLU_137458_0_0_1; -.
DR InParanoid; Q8N112; -.
DR OMA; AHTLHTQ; -.
DR OrthoDB; 1471751at2759; -.
DR PhylomeDB; Q8N112; -.
DR TreeFam; TF338480; -.
DR PathwayCommons; Q8N112; -.
DR SignaLink; Q8N112; -.
DR BioGRID-ORCS; 132228; 7 hits in 1062 CRISPR screens.
DR GenomeRNAi; 132228; -.
DR Pharos; Q8N112; Tdark.
DR PRO; PR:Q8N112; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N112; protein.
DR Bgee; ENSG00000179564; Expressed in apex of heart and 102 other tissues.
DR Genevisible; Q8N112; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031674; DUF4714.
DR PANTHER; PTHR37333; PTHR37333; 1.
DR Pfam; PF15833; DUF4714; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..164
FT /note="Leucine-rich single-pass membrane protein 2"
FT /id="PRO_0000242663"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 164 AA; 17868 MW; 809993458714252E CRC64;
MPSLAPDCPL LAMPEETQED SVAPMMPSQR SRGPLAPNHV HEVCLHQVES ISDLHSGAGT
LRPYLTEEAR PWDELLGVLP PSLCAQAGCS PVYRRGGFLL LLALLVLTCL VLALLAVYLS
VLQSESLRIL AHTLRTQEET LLKLRLASLS QLRRLNSSEA QAPS
