ID   LSOB_ECO57              Reviewed;         126 AA.
AC   Q7DKW4;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Antitoxin LsoB;
GN   Name=lsoB;
OS   Escherichia coli O157:H7.
OG   Plasmid pOSAK1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=9628576; DOI=10.1093/dnares/5.1.1;
RA   Makino K., Ishii K., Yasunaga T., Hattori M., Yokoyama K., Yatsudo H.C.,
RA   Kubota Y., Yamaichi Y., Iida T., Yamamoto K., Honda T., Han C.G.,
RA   Ohtsubo A., Kasamatsu M., Hayashi T., Kuhara S., Shinagawa H.;
RT   "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
RT   enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak.";
RL   DNA Res. 5:1-9(1998).
RN   [2]
RP   FUNCTION AS AN ANTITOXIN, AND INTERACTION WITH LSOA.
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=22403819; DOI=10.1111/j.1365-2958.2012.07975.x;
RA   Otsuka Y., Yonesaki T.;
RT   "Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli
RT   LsoA and RnlA toxins.";
RL   Mol. Microbiol. 83:669-681(2012).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       A labile antitoxin (half-life of 5.9 minutes) that inhibits the
CC       endonuclease activity of cognate toxin LsoA but not that of non-cognate
CC       toxin RnlA. {ECO:0000269|PubMed:22403819}.
CC   -!- SUBUNIT: Can form a complex with cognate toxin LsoA.
CC   -!- MISCELLANEOUS: This plasmid is only found in Sakai-derived strains of
CC       E.coli O157.
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DR   EMBL; AB011548; BAA31755.1; -; Genomic_DNA.
DR   RefSeq; NP_052605.1; NC_002127.1.
DR   RefSeq; WP_000710826.1; NZ_RWJR01000070.1.
DR   AlphaFoldDB; Q7DKW4; -.
DR   SMR; Q7DKW4; -.
DR   EnsemblBacteria; BAA31755; BAA31755; BAA31755.
DR   GeneID; 1789661; -.
DR   KEGG; ecs:pOSAK1_02; -.
DR   PATRIC; fig|386585.9.peg.2; -.
DR   HOGENOM; CLU_1978139_0_0_6; -.
DR   Proteomes; UP000000558; Plasmid pOSAK1.
DR   InterPro; IPR031834; RnlB/LsoB_antitoxin.
DR   Pfam; PF15933; RnlB_antitoxin; 1.
PE   1: Evidence at protein level;
KW   Plasmid; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..126
FT                   /note="Antitoxin LsoB"
FT                   /id="PRO_0000420766"
SQ   SEQUENCE   126 AA;  14527 MW;  51013EEA983148E1 CRC64;
     MKKDKKYQIE AIKNKDKTLF IVYATDIYSP SEFFSKIESD LKKKKSKGDV FFDLIIPNGG
     KKDRYVYTSF NGEKFSSYTL NKVTKTDEYN DLSELSASFF KKNFDKINVN LLSKATSFAL
     KKGIPI