LSP1A_DROME
ID LSP1A_DROME Reviewed; 816 AA.
AC P11995; Q9VYM4;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Larval serum protein 1 alpha chain;
DE AltName: Full=Hexamerin-1-alpha;
DE Flags: Precursor;
GN Name=Lsp1alpha; Synonyms=LSP1-a; ORFNames=CG2559;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-84, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=3097321; DOI=10.1016/0022-2836(86)90376-1;
RA Delaney S.J., Smith D.F., McClelland A., Sunkel C., Glover D.M.;
RT "Sequence conservation around the 5' ends of the larval serum protein 1
RT genes of Drosophila melanogaster.";
RL J. Mol. Biol. 189:1-11(1986).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52.
RX PubMed=16453657; DOI=10.1002/j.1460-2075.1985.tb04149.x;
RA Jowett T.;
RT "The regulatory domain of a larval serum protein gene in Drosophila
RT melanogaster.";
RL EMBO J. 4:3789-3795(1985).
CC -!- FUNCTION: Larval storage protein (LSP) which may serve as a store of
CC amino acids for synthesis of adult proteins. {ECO:0000250}.
CC -!- SUBUNIT: Heterohexamer, composed of three subunits, alpha, beta and
CC gamma.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000269|PubMed:3097321}.
CC -!- TISSUE SPECIFICITY: Larval hemolymph. {ECO:0000269|PubMed:3097321}.
CC -!- SIMILARITY: Belongs to the hemocyanin family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48168.2; -; Genomic_DNA.
DR EMBL; X03872; CAA27506.1; -; Genomic_DNA.
DR EMBL; X03368; CAA27066.1; -; Genomic_DNA.
DR PIR; A27144; A27144.
DR RefSeq; NP_511138.2; NM_078583.3.
DR AlphaFoldDB; P11995; -.
DR SMR; P11995; -.
DR BioGRID; 58598; 2.
DR IntAct; P11995; 1.
DR STRING; 7227.FBpp0073484; -.
DR PaxDb; P11995; -.
DR PRIDE; P11995; -.
DR EnsemblMetazoa; FBtr0073651; FBpp0073484; FBgn0002562.
DR GeneID; 32199; -.
DR KEGG; dme:Dmel_CG2559; -.
DR CTD; 32199; -.
DR FlyBase; FBgn0002562; Lsp1alpha.
DR VEuPathDB; VectorBase:FBgn0002562; -.
DR eggNOG; ENOG502QR98; Eukaryota.
DR GeneTree; ENSGT00940000165243; -.
DR HOGENOM; CLU_012213_1_0_1; -.
DR InParanoid; P11995; -.
DR OMA; ADNRMNF; -.
DR OrthoDB; 244455at2759; -.
DR PhylomeDB; P11995; -.
DR BioGRID-ORCS; 32199; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32199; -.
DR PRO; PR:P11995; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0002562; Expressed in arthropod fat body and 17 other tissues.
DR Genevisible; P11995; DM.
DR GO; GO:0005616; C:larval serum protein complex; IDA:FlyBase.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; -; 1.
DR Gene3D; 1.20.1370.10; -; 1.
DR Gene3D; 2.60.40.1520; -; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR013788; Hemocyanin/hexamerin.
DR InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR InterPro; IPR005203; Hemocyanin_C.
DR InterPro; IPR037020; Hemocyanin_C_sf.
DR InterPro; IPR005204; Hemocyanin_N.
DR InterPro; IPR036697; Hemocyanin_N_sf.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11511; PTHR11511; 1.
DR Pfam; PF03723; Hemocyanin_C; 1.
DR Pfam; PF00372; Hemocyanin_M; 1.
DR Pfam; PF03722; Hemocyanin_N; 1.
DR PRINTS; PR00187; HAEMOCYANIN.
DR SUPFAM; SSF48050; SSF48050; 1.
DR SUPFAM; SSF48056; SSF48056; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS00210; HEMOCYANIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal; Storage protein.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..816
FT /note="Larval serum protein 1 alpha chain"
FT /id="PRO_0000013333"
SQ SEQUENCE 816 AA; 98868 MW; 2D1C44176EB76194 CRC64;
MKFAIAFLAC VAVVTATAYH KTHDIKVADK AFLMKQKFLF EIVYRVEDPL MFEEYIAMGK
QFYFDKEHYT HFDLYMEKFF EAHKAHALLP KGEFFGALVK HHAKQARGLF NFFYYAKDWE
TFMTNVAFAR MHFNEGMFVY ALTLAVIHRD DFHGLVLPAI HEIFPQFFFN SKFVMEAEKF
DYEMWMKTSL YEKEYMDVYH KIPTFSSYEH GYKQGMAYGY GKTHGHGQTY EHEFGSMYQT
SDYMYMKDFK TWQWWKLMGL GEHWYSESNY ILRENIYEYN QESNWLTMMK DVKKFYMPVD
YSRDLYLYNE ESKLSYFTED LGWNSYWYYL NMDYSFFLDG KTFGLQNDRR GEWWLYNVHQ
LLSRYHMERL SHGLGEIPQF SWFHQIEMGY DPQLIYYNGI GYSYRKNYYE LETYGNFEML
DKITGFQQRI QNIVELGYYQ TTDGHMIDLR KPESIEIIGN MLQGNVDAID NIFFQFWYML
AHMYFADTHY YQMEVYPNVM LNFETMMRDP MFYMFYKSIA QVYFQFMHHL PKYTKEQLLM
PGVTLKHVEV SELVTYFDLV DFDVTNMLNG KMVFHEGQFL WDKSLFARQM RLNHKPFSYT
YTIDSARDEK VVIRAFLGPK FDEYGRMISL TDNRMNFMEI DEFTYTLKTG SNLITRKSTD
FAWTVKDRTT YTELYYYTMM AFDGKYDYPL DLTEPHCGFP DRLVLPMGWK KGMPMQMFFM
VVPYMAPQHE QFSTFDYTYS CGIGSGARHV DSLPFGYPFD REINEYEFHV PNMYFKDVTI
YHADTMEKYY NYKEYTNYGH FDYSFFNDYY TKYFKL
