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LSP1B_DROME
ID   LSP1B_DROME             Reviewed;         789 AA.
AC   P11996; Q29R17; Q9VPV2;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   03-AUG-2022, entry version 170.
DE   RecName: Full=Larval serum protein 1 beta chain;
DE   AltName: Full=Hexamerin-1-beta;
DE   Flags: Precursor;
GN   Name=Lsp1beta; Synonyms=Lsp1-b; ORFNames=CG4178;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Canton-S;
RX   PubMed=9128742; DOI=10.1111/j.1432-1033.1997.00199.x;
RA   Massey H.C. Jr., Kejzlarova-Lepesant J., Willis R.L., Castleberry A.B.,
RA   Benes H.;
RT   "The Drosophila Lsp-1 beta gene. A structural and phylogenetic analysis.";
RL   Eur. J. Biochem. 245:199-207(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-100.
RX   PubMed=3097321; DOI=10.1016/0022-2836(86)90376-1;
RA   Delaney S.J., Smith D.F., McClelland A., Sunkel C., Glover D.M.;
RT   "Sequence conservation around the 5' ends of the larval serum protein 1
RT   genes of Drosophila melanogaster.";
RL   J. Mol. Biol. 189:1-11(1986).
CC   -!- FUNCTION: Larval storage protein (LSP) which may serve as a store of
CC       amino acids for synthesis of adult proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer, composed of three subunits, alpha, beta and
CC       gamma.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Larval hemolymph.
CC   -!- SIMILARITY: Belongs to the hemocyanin family. {ECO:0000305}.
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DR   EMBL; U63556; AAB58821.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAF51434.1; -; Genomic_DNA.
DR   EMBL; AY069163; AAL39308.1; -; mRNA.
DR   EMBL; BT024223; ABC86285.1; -; mRNA.
DR   EMBL; X03873; CAA27507.1; -; Genomic_DNA.
DR   PIR; B27144; B27144.
DR   RefSeq; NP_001285556.1; NM_001298627.1.
DR   RefSeq; NP_476624.1; NM_057276.4.
DR   AlphaFoldDB; P11996; -.
DR   SMR; P11996; -.
DR   BioGRID; 59528; 2.
DR   IntAct; P11996; 1.
DR   STRING; 7227.FBpp0077690; -.
DR   PaxDb; P11996; -.
DR   DNASU; 33274; -.
DR   EnsemblMetazoa; FBtr0078025; FBpp0077690; FBgn0002563.
DR   EnsemblMetazoa; FBtr0345738; FBpp0311765; FBgn0002563.
DR   GeneID; 33274; -.
DR   KEGG; dme:Dmel_CG4178; -.
DR   CTD; 33274; -.
DR   FlyBase; FBgn0002563; Lsp1beta.
DR   VEuPathDB; VectorBase:FBgn0002563; -.
DR   eggNOG; ENOG502QR98; Eukaryota.
DR   HOGENOM; CLU_012213_1_0_1; -.
DR   InParanoid; P11996; -.
DR   OMA; MPGVTMK; -.
DR   OrthoDB; 244455at2759; -.
DR   PhylomeDB; P11996; -.
DR   BioGRID-ORCS; 33274; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Lsp1beta; fly.
DR   GenomeRNAi; 33274; -.
DR   PRO; PR:P11996; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0002563; Expressed in arthropod fat body and 18 other tissues.
DR   ExpressionAtlas; P11996; baseline and differential.
DR   Genevisible; P11996; DM.
DR   GO; GO:0005616; C:larval serum protein complex; IDA:FlyBase.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; -; 1.
DR   Gene3D; 1.20.1370.10; -; 1.
DR   Gene3D; 2.60.40.1520; -; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR013788; Hemocyanin/hexamerin.
DR   InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR   InterPro; IPR005203; Hemocyanin_C.
DR   InterPro; IPR037020; Hemocyanin_C_sf.
DR   InterPro; IPR005204; Hemocyanin_N.
DR   InterPro; IPR036697; Hemocyanin_N_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11511; PTHR11511; 1.
DR   Pfam; PF03723; Hemocyanin_C; 1.
DR   Pfam; PF00372; Hemocyanin_M; 1.
DR   Pfam; PF03722; Hemocyanin_N; 1.
DR   PRINTS; PR00187; HAEMOCYANIN.
DR   SUPFAM; SSF48050; SSF48050; 1.
DR   SUPFAM; SSF48056; SSF48056; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00210; HEMOCYANIN_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal; Storage protein.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..789
FT                   /note="Larval serum protein 1 beta chain"
FT                   /id="PRO_0000013334"
FT   CONFLICT        275
FT                   /note="T -> N (in Ref. 1; AAB58821)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        725
FT                   /note="S -> R (in Ref. 1; AAB58821)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   789 AA;  95914 MW;  AE12594515806A5B CRC64;
     MKIAIALLAC LGLAAAASFH QTHEVKIADK AFLMKQKFLF EIVYRVEDPL MFEDHIKQGE
     KFYFEESYYT HYDMYMKKFF EAYKAHALLP KGEFFGALVM SHAKQARGLF NFFYYAKDWE
     TFAANVAWAR MHVNEGMFVY ALTMAVIHRN DFHGLMLPSI YEIFPQFFFN SKFVFEAEKF
     DYEMWMKMTM YEKEYMDVYY KTNGYDYSTM YRSSDYTYMK DFKTWQWWKL MGLGEHWYTE
     DKFILRENIY EFNQETKWLS MMKDVKKFYM PVDYTRDLNL YNKESKLSYF TEDLGWNAYW
     YYLNMDYSFF LDGNTFDLKN DRRGEWWLYN VHQLLSRYYM ERLSHGFGEI PEFSWYQQIE
     MGYDPQLIYY NGIGYSFRKN YYEMETYANY DMLDKITGFL KRIHNIVEMG YYKTADGHTI
     DLRKPEAIEF IGNMLQGNVD AMDKMFYQFW YMLAHMYFAD ADYYQMDVYP NVMLNFETMM
     RDPMYYMFYK SIAQVYFQFM HYLPKYTKEQ LLMPGVTMKN VEVSDLTTYF DLVDFDVTNM
     LNDKMIFQDG KFVWDMSLFA RQMRLNHKPF TYTYTIESEK VEKVVIRAFL GPKFDEFGKV
     ISLAENRMNF MEIDEFYYEL KAGTNKITRK SSEFYWTVKD RTTYTELYYY TMMAFDGKYD
     FPLDISEPHC GFPDRLVLPM GWQKGMPMQM FFMVVPYVAP AHEQFSTFDY TYSCGIGSGA
     RYVDSLPFGY PFDRAIDEYE FFVPNMYFKD VSIYHADTME PYYKYKSYSN YGHFDYTFFN
     DYYTKYFKF
 
 
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