5HTR_HELVI
ID 5HTR_HELVI Reviewed; 466 AA.
AC Q25190;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=5-hydroxytryptamine receptor;
DE Short=5-HT receptor;
DE AltName: Full=Serotonin receptor;
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Antenna;
RX PubMed=9014328; DOI=10.1016/s0965-1748(96)00031-8;
RA von Nickisch-Rosenegk E., Krieger J., Kubick S., Laage R., Strobel J.,
RA Strotmann J., Breer H.;
RT "Cloning of biogenic amine receptors from moths (Bombyx mori and Heliothis
RT virescens).";
RL Insect Biochem. Mol. Biol. 26:817-827(1996).
CC -!- FUNCTION: This is a receptor for 5-hydroxytryptamine (serotonin), a
CC biogenic hormone that function as a neurotransmitter, a hormone, and a
CC mitogen. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X95605; CAA64863.1; -; mRNA.
DR AlphaFoldDB; Q25190; -.
DR SMR; Q25190; -.
DR PRIDE; Q25190; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..466
FT /note="5-hydroxytryptamine receptor"
FT /id="PRO_0000068986"
FT TOPO_DOM 1..66
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 67..89
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 90..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 100..121
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 122..136
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 137..158
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 159..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 178..200
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 201..228
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 229..250
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 251..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 387..410
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 411..419
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 420..442
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 443..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 135..215
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 466 AA; 52094 MW; AD29A38EC37106EB CRC64;
MNASRLPGFN DTSQDQPYPT SSEWFDGSNC SWVDAVSWGC NVTINGTSTN ATSTDVTSFV
LMAVTSVVLA LIILATIVGN VFVIAAIIIE RNLQNVANYL VASLAVADLM VACLVMPLGA
VYEVSQGWIL GPELCDMWTS SDVLCSSASI LHLVAIATDR YWAVTDVDYI HIRNEKRIFT
MIVLVWGAAL VVSLAPQLGW KDPDYLARIT QQQKCLVSQD LAYQIFATMS TFYVPLAVIL
ILYWKIFQTA RRRIRRRRDP PPPRPTSADG ATPSGRPVQS ARDRRFVKKR FLNLKKCNQR
TRAETLAAAL LLTEGQSTST VDTLDEEPRT TAFTINEKVP PSVSPEKSSS TVTNGSKPER
AIVPAPTHRE KKESLEAKRE RKAAKTLAII TGAFVFCWLP FFIMALVMPI CQTCVISDYL
ASFFLWLGYF NSTLNPVIYT IFSPDFRQAF ARILFGTHRR RRYKKF
