ID   LSRA_ECO24              Reviewed;         333 AA.
AC   A7ZLX1;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Putative autoinducer 2 import ATP-binding protein LsrA homolog;
GN   Name=lsrA; OrderedLocusNames=EcE24377A_1714;
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC;
RX   PubMed=18676672; DOI=10.1128/jb.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. AI-2
CC       autoinducer porter (TC 3.A.1.2.8) family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. The C-terminus is
CC       shorter than in related proteins. In addition, LsrC and LsrD permeases
CC       are missing, this ABC transporter is therefore probably not functional
CC       in strain E24377A. {ECO:0000305}.
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DR   EMBL; CP000800; ABV20446.1; -; Genomic_DNA.
DR   RefSeq; WP_012138442.1; NC_009801.1.
DR   AlphaFoldDB; A7ZLX1; -.
DR   SMR; A7ZLX1; -.
DR   EnsemblBacteria; ABV20446; ABV20446; EcE24377A_1714.
DR   KEGG; ecw:EcE24377A_1714; -.
DR   HOGENOM; CLU_000604_92_2_6; -.
DR   OMA; DNMFMGR; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1905887; P:autoinducer AI-2 transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR030281; LsrA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43790:SF2; PTHR43790:SF2; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   5: Uncertain;
KW   ATP-binding; Nucleotide-binding.
FT   CHAIN           1..333
FT                   /note="Putative autoinducer 2 import ATP-binding protein
FT                   LsrA homolog"
FT                   /id="PRO_0000351293"
FT   DOMAIN          12..240
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   333 AA;  36048 MW;  36D08CCBAE1F7F93 CRC64;
     MQTSDTRALP LLCARSVYKQ YSGVNVLKGI DFTLHQGEVH ALLGGNGAGK STLMKIIAGI
     TPADSGTLEI GGNNYARLTP VHAHQLGIYL VPQEPLLFPS LSIKENILFG MAKKQLSMQK
     MKNLLAALGC QFDLHSLAGS LDVADRQMVE ILRGLMRDSR ILILDEPTAS LTPAETERLF
     TRLQELLATG VGIVFISHKL PEIRQIADRI SVMRDGTIAL SGKTSELSTD DIIQAITPVV
     REKSLSASQK LWLELPGNRP QHAAGTPVLT LENLTGEGFR NVSMTLNAGE ILGLAGLVGA
     GRTELAETLY GLRTLRGFIA RFQLTAPYVR SMP