ID   LSRB_KLEP7              Reviewed;         333 AA.
AC   A6TEB5;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Autoinducer 2-binding protein LsrB;
DE            Short=AI-2-binding protein LsrB;
DE   Flags: Precursor;
GN   Name=lsrB; OrderedLocusNames=KPN78578_34750; ORFNames=KPN_03504;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC       autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and
CC       LsrD permeases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC       two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC       (LsrB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000647; ABR78899.1; -; Genomic_DNA.
DR   RefSeq; WP_015959041.1; NC_009648.1.
DR   AlphaFoldDB; A6TEB5; -.
DR   SMR; A6TEB5; -.
DR   STRING; 272620.KPN_03504; -.
DR   DNASU; 5341471; -.
DR   EnsemblBacteria; ABR78899; ABR78899; KPN_03504.
DR   KEGG; kpn:KPN_03504; -.
DR   HOGENOM; CLU_037628_3_0_6; -.
DR   OMA; KQVNNPY; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   CDD; cd20003; PBP1_LsrB_Quorum_Sensing; 1.
DR   InterPro; IPR030159; LsrB.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   PANTHER; PTHR46847:SF4; PTHR46847:SF4; 1.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..333
FT                   /note="Autoinducer 2-binding protein LsrB"
FT                   /id="PRO_0000351322"
SQ   SEQUENCE   333 AA;  35886 MW;  1D676A29150AA065 CRC64;
     MKLKLIVLAL TMSVVTAQAA DRIAFIPKLV GVGFFTSGGN GAKEAGKALG VDVTYDGPTE
     PSVSGQVQLI NNFVNQGYNA IIVSAVSPDG LCPALKRAMQ RGVKVLTWDS DTKPECRSIY
     INQGTPQQLG GLLVEMAEKQ VSKPAAKVAF FYSSPTVTDQ NQWVKEAKAK IEKEHPQWQI
     VTTQFGYNDA TKSLQTAEGI LKAYPDLDAI IAPDANALPA AAQAAENLKR QGVAIVGFST
     PNVMRPYVER GTVKAFGLWD VVKQGKIAVN VADRLLKKGD LNVGDSVEVK DIGSLKVEPN
     SVQGYQYEAK GNGIVLLPER VVFSKENINN YDF