LSRB_SALTI
ID LSRB_SALTI Reviewed; 340 AA.
AC Q8Z2X8; Q7C6A1;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Autoinducer 2-binding protein LsrB;
DE Short=AI-2-binding protein LsrB;
DE Flags: Precursor;
GN Name=lsrB; OrderedLocusNames=STY3793, t3541;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and
CC LsrD permeases (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC (LsrB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC {ECO:0000305}.
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DR EMBL; AE014613; AAO71048.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD09546.1; -; Genomic_DNA.
DR RefSeq; NP_457975.1; NC_003198.1.
DR RefSeq; WP_000090739.1; NZ_WSUR01000010.1.
DR PDB; 5GTA; X-ray; 3.00 A; A=1-340.
DR PDBsum; 5GTA; -.
DR AlphaFoldDB; Q8Z2X8; -.
DR SMR; Q8Z2X8; -.
DR STRING; 220341.16504662; -.
DR DrugBank; DB04346; (2r,4s)-2-Methyl-2,3,3,4-Tetrahydroxytetrahydrofuran.
DR EnsemblBacteria; AAO71048; AAO71048; t3541.
DR KEGG; stt:t3541; -.
DR KEGG; sty:STY3793; -.
DR PATRIC; fig|220341.7.peg.3871; -.
DR eggNOG; COG1879; Bacteria.
DR HOGENOM; CLU_037628_3_0_6; -.
DR OMA; KQVNNPY; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR CDD; cd20003; PBP1_LsrB_Quorum_Sensing; 1.
DR InterPro; IPR030159; LsrB.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR025997; SBP_2_dom.
DR PANTHER; PTHR46847:SF4; PTHR46847:SF4; 1.
DR Pfam; PF13407; Peripla_BP_4; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Periplasm; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..340
FT /note="Autoinducer 2-binding protein LsrB"
FT /id="PRO_0000351329"
FT STRAND 29..33
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 40..55
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 70..82
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 86..90
FT /evidence="ECO:0007829|PDB:5GTA"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 99..106
FT /evidence="ECO:0007829|PDB:5GTA"
FT TURN 107..109
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 111..117
FT /evidence="ECO:0007829|PDB:5GTA"
FT TURN 121..123
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 125..131
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 133..148
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 150..160
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 165..181
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 185..192
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 197..210
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 216..219
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 224..234
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 241..245
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 248..256
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 263..266
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 268..283
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 293..296
FT /evidence="ECO:0007829|PDB:5GTA"
FT TURN 297..299
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 300..305
FT /evidence="ECO:0007829|PDB:5GTA"
FT HELIX 307..309
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 319..323
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 327..330
FT /evidence="ECO:0007829|PDB:5GTA"
FT STRAND 332..337
FT /evidence="ECO:0007829|PDB:5GTA"
SQ SEQUENCE 340 AA; 36788 MW; 648C61815B49B417 CRC64;
MARHSIKMIA LLTAFGLASA VMTVQAAERI AFIPKLVGVG FFTSGGNGAQ EAGKALGIDV
TYDGPTEPSV SGQVQLVNNF VNQGYDAIIV SAVSPDGLCP ALKRAMQRGV KILTWDSDTK
PECRSYYINQ GTPKQLGSML VEMAAHQVDK EKAKVAFFYS SPTVTDQNQW VKEAKAKISQ
EHPGWEIVTT QFGYNDATKS LQTAEGIIKA YPDLDAIIAP DANALPAAAQ AAENLKRNNL
AIVGFSTPNV MRPYVQRGTV KEFGLWDVVQ QGKISVYVAN ALLKNMPMNV GDSLDIPGIG
KVTVSPNSEQ GYHYEAKGNG IVLLPERVIF NKDNIDKYDF
