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LSRB_YERPE
ID   LSRB_YERPE              Reviewed;         339 AA.
AC   Q74PW2; Q8CZM9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Autoinducer 2-binding protein LsrB;
DE            Short=AI-2-binding protein LsrB;
DE   Flags: Precursor;
GN   Name=lsrB; OrderedLocusNames=YPO0409, y3772, YP_3772;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC       autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and
CC       LsrD permeases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC       two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC       (LsrB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM87317.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL19090.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM87317.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS63920.1; -; Genomic_DNA.
DR   PIR; AH0050; AH0050.
DR   RefSeq; WP_002209189.1; NZ_WUCM01000002.1.
DR   RefSeq; YP_002345486.1; NC_003143.1.
DR   PDB; 3T95; X-ray; 1.75 A; A=26-339.
DR   PDBsum; 3T95; -.
DR   AlphaFoldDB; Q74PW2; -.
DR   SMR; Q74PW2; -.
DR   IntAct; Q74PW2; 1.
DR   STRING; 214092.YPO0409; -.
DR   PaxDb; Q74PW2; -.
DR   DNASU; 1148719; -.
DR   EnsemblBacteria; AAM87317; AAM87317; y3772.
DR   EnsemblBacteria; AAS63920; AAS63920; YP_3772.
DR   GeneID; 57974201; -.
DR   KEGG; ype:YPO0409; -.
DR   KEGG; ypk:y3772; -.
DR   KEGG; ypm:YP_3772; -.
DR   PATRIC; fig|214092.21.peg.649; -.
DR   eggNOG; COG1879; Bacteria.
DR   HOGENOM; CLU_037628_3_0_6; -.
DR   OMA; KQVNNPY; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR   CDD; cd20003; PBP1_LsrB_Quorum_Sensing; 1.
DR   InterPro; IPR030159; LsrB.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   PANTHER; PTHR46847:SF4; PTHR46847:SF4; 1.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..339
FT                   /note="Autoinducer 2-binding protein LsrB"
FT                   /id="PRO_0000351333"
FT   STRAND          28..32
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          34..38
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           39..55
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          58..61
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           69..81
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          85..89
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          92..95
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           98..106
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          110..116
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           120..122
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          124..129
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           132..147
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          150..159
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           164..180
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          184..191
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           196..209
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          215..218
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           223..233
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          240..244
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           247..255
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          262..264
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           267..284
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          292..295
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   TURN            296..298
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          299..304
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           306..309
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          319..322
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   STRAND          327..329
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   TURN            331..333
FT                   /evidence="ECO:0007829|PDB:3T95"
FT   HELIX           334..336
FT                   /evidence="ECO:0007829|PDB:3T95"
SQ   SEQUENCE   339 AA;  36708 MW;  43DF0D22B6239FD3 CRC64;
     MRTQRLKKLA LVCALGFACI TTAQAAERIA FIPKLVGVGF FTSGGKGAVD AGKALGVDVT
     YDGPTEPSVS GQVQLINNFV NQGYNAIVVS AVSPDGLCPA LKRAMQRGVK ILTWDSDTKP
     ECRSVYINQG TPNQLGSMLV DMAANQVKKE QAKVAFFYSS PTVTDQNQWV NEAKKKIQQE
     HPGWEIVTTQ FGYNDATKSL QTAEGILKAY ADLDAIIAPD ANALPAAAQA AENLKRANVA
     IVGFSTPNVM RPYVERGTVK EFGLWDVVNQ GKISVYVANE MLKKGDLNVG DKIDIPNIGV
     VEVSPNRVQG YDYEAKGNGI VLLPQRVIFT KENISKYDF
 
 
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