ID   LSRC_KLEP7              Reviewed;         344 AA.
AC   A6TEB7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Autoinducer 2 import system permease protein LsrC;
DE            Short=AI-2 import system permease protein LsrC;
GN   Name=lsrC; OrderedLocusNames=KPN78578_34770; ORFNames=KPN_03506;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC       autoinducer 2 (AI-2) import. Probably responsible for the translocation
CC       of the substrate across the membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC       two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC       (LsrB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. AraH/RbsC subfamily. {ECO:0000305}.
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DR   EMBL; CP000647; ABR78901.1; -; Genomic_DNA.
DR   RefSeq; WP_015959043.1; NC_009648.1.
DR   AlphaFoldDB; A6TEB7; -.
DR   STRING; 272620.KPN_03506; -.
DR   EnsemblBacteria; ABR78901; ABR78901; KPN_03506.
DR   KEGG; kpn:KPN_03506; -.
DR   HOGENOM; CLU_028880_0_1_6; -.
DR   OMA; KRMLKMH; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..344
FT                   /note="Autoinducer 2 import system permease protein LsrC"
FT                   /id="PRO_0000351342"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          323..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  36171 MW;  E5BB0228BB5B205A CRC64;
     MKTLLKNREL SAFFAIVALF VVLVALNPAY FILQTLAMIF ASSQILCLLA LGATLVMLTR
     NIDVSVGSTV GLCAIAVGVA LNYGYGLATA IAFALAIGAL AGAFNGLLVV GLRIPAIVAT
     LGTLGLYRGV MLLWTGGKWI EGLPDSLKSL SEPAFIGVSP LGWLVLALLL AGGWLLSRTA
     FGRDFYAVGD NLAAARQLGV AVNRTRMLAF TLNGMLAACA GIVFAAQIGF VPNQTGSGLE
     MKAIAACVLG GISLLGGTGT LLGAFLGAFF LTQIDTVLVL FRLPAWWNDF IAGLVLLGVL
     VLDGRLRQAL ARHQRALKYS RFQPGNKGSK QVARFPERKS KEVA