LSRC_SALTY
ID LSRC_SALTY Reviewed; 347 AA.
AC Q8ZKQ3;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Autoinducer 2 import system permease protein LsrC;
DE Short=AI-2 import system permease protein LsrC;
GN Name=lsrC; OrderedLocusNames=STM4075;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP FUNCTION IN AI-2 IMPORT, AND INDUCTION.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=11722742; DOI=10.1046/j.1365-2958.2001.02669.x;
RA Taga M.E., Semmelhack J.L., Bassler B.L.;
RT "The LuxS-dependent autoinducer AI-2 controls the expression of an ABC
RT transporter that functions in AI-2 uptake in Salmonella typhimurium.";
RL Mol. Microbiol. 42:777-793(2001).
CC -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC autoinducer 2 (AI-2) import. Probably responsible for the translocation
CC of the substrate across the membrane (Probable).
CC {ECO:0000305|PubMed:11722742}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC (LsrB). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- INDUCTION: In the absence of AI-2, repressed by LsrR. Induced by AI-2,
CC via release of the LsrR repressor. {ECO:0000269|PubMed:11722742}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. AraH/RbsC subfamily. {ECO:0000305}.
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DR EMBL; AE006468; AAL22915.1; -; Genomic_DNA.
DR RefSeq; NP_462956.1; NC_003197.2.
DR RefSeq; WP_000911134.1; NC_003197.2.
DR AlphaFoldDB; Q8ZKQ3; -.
DR STRING; 99287.STM4075; -.
DR PaxDb; Q8ZKQ3; -.
DR EnsemblBacteria; AAL22915; AAL22915; STM4075.
DR GeneID; 1255602; -.
DR KEGG; stm:STM4075; -.
DR PATRIC; fig|99287.12.peg.4295; -.
DR HOGENOM; CLU_028880_0_1_6; -.
DR OMA; KRMLKMH; -.
DR PhylomeDB; Q8ZKQ3; -.
DR BioCyc; SENT99287:STM4075-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..347
FT /note="Autoinducer 2 import system permease protein LsrC"
FT /id="PRO_0000351350"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 347 AA; 36926 MW; 509EDD0083DBAE48 CRC64;
MLKFIQNNRE ATALLAIVCL FVFPGALDSQ YLSVQTLTMV FSSAQILMLL AIGATMVMLT
RNIDVSVGST TGMCAVLLGV MLNAGYSLPV ACLATLILGI VAGFFNGVLV AWLKIPAIVA
TLGTLGLYRG IMLLWTGGKW IEGLPAGLKQ LSAPVFLGIS AIGWFTLVLA LLMAWLLAKT
AFGRNFYATG DNLQGARQLG VRTEMVRIMA FSLNGGMAAL AGIVFASQIG FIPNQTGTGL
EMKAIAACVL GGISLLGGSG TVIGAILGAY FLTQIDSVLV LLRIPAWWND FIAGLVLLGV
LVFDGRLRCA LQRNLRRQKY ARFISPPTPL QTEAKTHAQQ NKNKEVA