LSRD_SALTY
ID LSRD_SALTY Reviewed; 332 AA.
AC Q8ZKQ2;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Autoinducer 2 import system permease protein LsrD;
DE Short=AI-2 import system permease protein LsrD;
GN Name=lsrD; OrderedLocusNames=STM4076;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP FUNCTION IN AI-2 IMPORT, AND INDUCTION.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=11722742; DOI=10.1046/j.1365-2958.2001.02669.x;
RA Taga M.E., Semmelhack J.L., Bassler B.L.;
RT "The LuxS-dependent autoinducer AI-2 controls the expression of an ABC
RT transporter that functions in AI-2 uptake in Salmonella typhimurium.";
RL Mol. Microbiol. 42:777-793(2001).
CC -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC autoinducer 2 (AI-2) import. Probably responsible for the translocation
CC of the substrate across the membrane (Probable).
CC {ECO:0000305|PubMed:11722742}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC (LsrB). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- INDUCTION: In the absence of AI-2, repressed by LsrR. Induced by AI-2,
CC via release of the LsrR repressor. {ECO:0000269|PubMed:11722742}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. AraH/RbsC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL22916.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE006468; AAL22916.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_462957.1; NC_003197.2.
DR AlphaFoldDB; Q8ZKQ2; -.
DR STRING; 99287.STM4076; -.
DR PaxDb; Q8ZKQ2; -.
DR EnsemblBacteria; AAL22916; AAL22916; STM4076.
DR GeneID; 1255603; -.
DR KEGG; stm:STM4076; -.
DR PATRIC; fig|99287.12.peg.4296; -.
DR HOGENOM; CLU_028880_0_0_6; -.
DR OMA; LSLHREW; -.
DR PhylomeDB; Q8ZKQ2; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..332
FT /note="Autoinducer 2 import system permease protein LsrD"
FT /id="PRO_0000351377"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 332 AA; 35133 MW; 9C4CDFEB0AAAEBA6 CRC64;
MNPWRRYSWE IALAALLIFE ILAFGLINPR LLDINVLLFS TSDFICIGIV ALPLTMVIVS
GGMDISFGST IGLCAITLGV LFQLGMPLPL AIIITLLLGA ICGLINAGLI IYTGVNPLVI
TLGTMYLFGG SALLLSGMAG ATGYEGIGGF PTAFTDFANI SFLGIPMPLI FFLVCCLFFW
LLMHRTHMGR NVFLIGQSAR VAQYSAIPVN RTLYTVYAMT GCASAIAAVL LVSYFGSARS
DLGASFLMPA ITAVVLGGAN IYGGSGSIMG SALAALLVGF LQQGLQMAGV PNQISSALSG
ALLIVVVVGR SVSLHRHQIL EWYSRRRNAH QA
