ID   LSRR_ECO24              Reviewed;         317 AA.
AC   A7ZLX0;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=EcE24377A_1713;
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC;
RX   PubMed=18676672; DOI=10.1128/jb.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- FUNCTION: Regulates transcription of many different genes. In the
CC       absence of autoinducer 2 (AI-2), represses transcription of the lsr
CC       operon and its own transcription. In the presence of AI-2, LsrR is
CC       inactivated by binding phospho-AI-2, leading to the transcription of
CC       the lsr genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000800; ABV20760.1; -; Genomic_DNA.
DR   RefSeq; WP_000154340.1; NC_009801.1.
DR   AlphaFoldDB; A7ZLX0; -.
DR   SMR; A7ZLX0; -.
DR   EnsemblBacteria; ABV20760; ABV20760; EcE24377A_1713.
DR   GeneID; 66674634; -.
DR   KEGG; ecw:EcE24377A_1713; -.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   OMA; CTVVQLT; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..317
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351614"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  33814 MW;  B60AA1F47B7DA3B4 CRC64;
     MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL LEKGHQSGII
     RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG RLGIGAAHML MSLLQPQQML
     AIGFGEATMN TLQRLSGFIS SQQIRLVTLS GGVGSYMTGI GQLNAACSVN IIPAPLRASS
     ADIARTLKNE NCVKDVLLAA QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA
     VGDILGYFFD AKGDVVTDIK IHNELIGLPL SSLKTIPVRV GVAGGENKAE AIAAAMKGGY
     INALVTDQDT AAAILRS