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LSRR_ECOSM
ID   LSRR_ECOSM              Reviewed;         317 AA.
AC   B1LFA3;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=EcSMS35_1660;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: Regulates transcription of many different genes. In the
CC       absence of autoinducer 2 (AI-2), represses transcription of the
CC       lsrACDBFG operon and its own transcription. In the presence of AI-2,
CC       LsrR is inactivated by binding phospho-AI-2, leading to the
CC       transcription of the lsr genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000970; ACB16095.1; -; Genomic_DNA.
DR   RefSeq; WP_000154347.1; NC_010498.1.
DR   AlphaFoldDB; B1LFA3; -.
DR   SMR; B1LFA3; -.
DR   PRIDE; B1LFA3; -.
DR   EnsemblBacteria; ACB16095; ACB16095; EcSMS35_1660.
DR   KEGG; ecm:EcSMS35_1660; -.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   OMA; CTVVQLT; -.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..317
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351613"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  33754 MW;  D98281F8D4AB764A CRC64;
     MTINDSVISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL LEKGHQSGII
     RVQINSRFEG CLEYETQLCR QFSLQHVRVI PGLADADVGG RLGIGAAHML MSLLQPQQML
     AIGFGEATMN TLQRLSGFIS SQQIRLVTLS GGVGSYMTGI GQLNAACSVN IIPAPLRASS
     ADIAHTLKNE NCVKDVLLAA QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA
     VGDILGYFFD AKGDVVTDIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY
     INALVTDQDT AAAILRS
 
 
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