ID   LSRR_KLEP7              Reviewed;         323 AA.
AC   A6TEB9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=KPN78578_34790; ORFNames=KPN_03508;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates transcription of many different genes. In the
CC       absence of autoinducer 2 (AI-2), represses transcription of the
CC       lsrACDBFG operon and its own transcription. In the presence of AI-2,
CC       LsrR is inactivated by binding phospho-AI-2, leading to the
CC       transcription of the lsr genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000647; ABR78903.1; -; Genomic_DNA.
DR   RefSeq; WP_004174223.1; NC_009648.1.
DR   AlphaFoldDB; A6TEB9; -.
DR   SMR; A6TEB9; -.
DR   STRING; 272620.KPN_03508; -.
DR   EnsemblBacteria; ABR78903; ABR78903; KPN_03508.
DR   GeneID; 66602042; -.
DR   KEGG; kpn:KPN_03508; -.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   OMA; SNEFITH; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..323
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351617"
FT   DNA_BIND        37..56
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  34452 MW;  F69A66E8C90738F5 CRC64;
     MSEKRITEEN RYAGLALAEE ELVARVAWCY YHDGLTQNDI GERLGLPRLK ISRLLEKGRQ
     SGVIRVQINS RYEGCLALES ELQQRFGLKI ARVLPALNTP PMNTRLGIGA AQSLMGILQP
     GQLLAVGFGE ATMSCLQHLS GFIGSQQVRL VTLSGGVGPY MTGIGQLDAA CSVSIIPAPL
     RVSSAEVAEI LRRESSVRDV MLAATAADAA VVGIGAIDQR RDATILRSGY ISEGEQLMYA
     RKGAVGDILG YFLQADGRPV EGLEIHRELL GVTLDELAQL PTIVGVAGGE QKAQAIHAAL
     IGKRINGLVT EETTARAVLA LAS