ID   LSRR_PHOLL              Reviewed;         307 AA.
AC   Q7N2E0;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=plu3142;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Regulates transcription of many different genes. In the
CC       absence of autoinducer 2 (AI-2), represses transcription of the
CC       lsrACDBFG operon and its own transcription. In the presence of AI-2,
CC       LsrR is inactivated by binding phospho-AI-2, leading to the
CC       transcription of the lsr genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE15516.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571869; CAE15516.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q7N2E0; -.
DR   SMR; Q7N2E0; -.
DR   STRING; 243265.plu3142; -.
DR   EnsemblBacteria; CAE15516; CAE15516; plu3142.
DR   KEGG; plu:plu3142; -.
DR   eggNOG; COG2390; Bacteria.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00325; Crp; 1.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..307
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351618"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  32992 MW;  E5BD8BAD501ABBB5 CRC64;
     MSEEELLARI AWFYYHDGLT QGDIGDLLGL SRLKVSRLLE KGRQSGVIRV QINSRYEGCL
     ALEDTLQKHF SLKQVRVLPA LANMNLSARL GVGAAHLLMA LIEPQQLLAV GFGETTMCAL
     QHLSGFISSQ QIRLVTLSGG VGPYMTGIGQ LDAACSINII PAPLRASTAQ VAETFRQESS
     VRDVLLAACA ADIAIVGIGA VNQQQQATIM RSGYISGGEQ LMFGRKGAVG DILGYFMRAD
     GELVEDMQIH QELIGISMPE LKTIPTVIGV AGGEEKAEAI IAALNGQYIN GLVTEEQTAR
     VMLNLLR