ID   LSRR_SALCH              Reviewed;         319 AA.
AC   Q57HE3;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=SCH_3963;
OS   Salmonella choleraesuis (strain SC-B67).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
CC   -!- FUNCTION: In the absence of autoinducer 2 (AI-2), represses
CC       transcription of the lsrACDBFGE operon and its own transcription. In
CC       the presence of AI-2, LsrR is inactivated by binding phospho-AI-2,
CC       leading to the transcription of the lsr genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE017220; AAX67869.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q57HE3; -.
DR   SMR; Q57HE3; -.
DR   EnsemblBacteria; AAX67869; AAX67869; SCH_3963.
DR   KEGG; sec:SCH_3963; -.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   OMA; CTVVQLT; -.
DR   Proteomes; UP000000538; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..319
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351619"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  34405 MW;  1148791B1413909A CRC64;
     MSDNTLVSDY GMCEEEQMAR IAWFYYHDGL TQSEISERLG LTRLKVSRLL EKGHQSGIIR
     VQINSRFEGC LEYENALRNH FALQNIRVLP ALPDADIGLR LGIGAAHMLM ESLRPQQLLA
     VGFGEATMTT LKHLSGFISA QQIRLVTLSG GVGPYMTGIG QLDAACSVSI MPAPLRASSQ
     EIACTLRNEN SVRDVMLTAQ AADAAIVGIG AINQKDQASI LKSGYITQGE QLMIGRKGAV
     GDILGYFFDA HGEIIPGIKI HNELIGLKLN SLSTIPTVIG VAGGEQKAEA IIAAMRGNYI
     NALVTDQKTA GKIIQLIEK