ID   LSRR_SALTI              Reviewed;         319 AA.
AC   Q8Z2X4; Q7C697;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=STY3797, t3545;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: In the absence of autoinducer 2 (AI-2), represses
CC       transcription of the lsrACDBFGE operon and its own transcription. In
CC       the presence of AI-2, LsrR is inactivated by binding phospho-AI-2,
CC       leading to the transcription of the lsr genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE014613; AAO71052.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD09550.1; -; Genomic_DNA.
DR   RefSeq; NP_457979.1; NC_003198.1.
DR   RefSeq; WP_001283049.1; NZ_WSUR01000010.1.
DR   AlphaFoldDB; Q8Z2X4; -.
DR   SMR; Q8Z2X4; -.
DR   STRING; 220341.16504666; -.
DR   EnsemblBacteria; AAO71052; AAO71052; t3545.
DR   KEGG; stt:t3545; -.
DR   KEGG; sty:STY3797; -.
DR   PATRIC; fig|220341.7.peg.3876; -.
DR   eggNOG; COG2390; Bacteria.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   OMA; CTVVQLT; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..319
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351622"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  34450 MW;  B5001F3110EA0AD5 CRC64;
     MSDNTLVSDY GMCEEEQVAR IAWFYYHDGL TQSEISERLG LTRLKVSRLL EKGHQSGIIR
     VQINSRFEGC LEYENALRNH FALQNIRVLP ALPDADIGLR LGIGAAHMLM ESLRPQQLLA
     VGFGEATMTT LKRLSGFISA QQIRLVTLSG GVGPYMTGIG QLDAACSVSI MPAPLRASSQ
     EIACTLRNEN SVRDVMLTAQ AADAAIVGIG AINQKDQASI LKSGYITQGE QLMIGRKGAV
     GDILGYFFDA HGEIIPDIKI HNELIGLKLN SLSTIPTVIG VAGGEQKAEA IIAAMRGNYI
     NALVTDQKTA GKIIQLIEK