ID   LSRR_SALTY              Reviewed;         319 AA.
AC   Q8ZKQ5;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Transcriptional regulator LsrR;
GN   Name=lsrR; OrderedLocusNames=STM4073;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=11722742; DOI=10.1046/j.1365-2958.2001.02669.x;
RA   Taga M.E., Semmelhack J.L., Bassler B.L.;
RT   "The LuxS-dependent autoinducer AI-2 controls the expression of an ABC
RT   transporter that functions in AI-2 uptake in Salmonella typhimurium.";
RL   Mol. Microbiol. 42:777-793(2001).
RN   [3]
RP   FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=14622426; DOI=10.1046/j.1365-2958.2003.03781.x;
RA   Taga M.E., Miller S.T., Bassler B.L.;
RT   "Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium.";
RL   Mol. Microbiol. 50:1411-1427(2003).
RN   [4]
RP   BINDING TO PHOSPHO-AI-2.
RX   PubMed=17274596; DOI=10.1021/cb600444h;
RA   Xavier K.B., Miller S.T., Lu W., Kim J.H., Rabinowitz J., Pelczer I.,
RA   Semmelhack M.F., Bassler B.L.;
RT   "Phosphorylation and processing of the quorum-sensing molecule autoinducer-
RT   2 in enteric bacteria.";
RL   ACS Chem. Biol. 2:128-136(2007).
CC   -!- FUNCTION: In the absence of autoinducer 2 (AI-2), represses
CC       transcription of the lsrACDBFGE operon and its own transcription. In
CC       the presence of AI-2, LsrR is inactivated by binding phospho-AI-2,
CC       leading to the transcription of the lsr genes.
CC       {ECO:0000269|PubMed:11722742, ECO:0000269|PubMed:14622426}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE006468; AAL22913.1; -; Genomic_DNA.
DR   RefSeq; NP_462954.1; NC_003197.2.
DR   RefSeq; WP_001283048.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZKQ5; -.
DR   SMR; Q8ZKQ5; -.
DR   STRING; 99287.STM4073; -.
DR   PaxDb; Q8ZKQ5; -.
DR   EnsemblBacteria; AAL22913; AAL22913; STM4073.
DR   GeneID; 1255600; -.
DR   KEGG; stm:STM4073; -.
DR   PATRIC; fig|99287.12.peg.4293; -.
DR   HOGENOM; CLU_054506_0_1_6; -.
DR   OMA; CTVVQLT; -.
DR   PhylomeDB; Q8ZKQ5; -.
DR   BioCyc; SENT99287:STM4073-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..319
FT                   /note="Transcriptional regulator LsrR"
FT                   /id="PRO_0000351623"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  34450 MW;  B5001F3660EA0AD5 CRC64;
     MSDNTLVSDY GMCEEEQVAR IAWFYYHDGL TQSEISERLG LTRLKVSRLL EKGHQSGIIR
     VQINSRFEGC LEYENALRNH FALQNIRVLP ALPDADIGLR LGIGAAHMLM ESLRPQQLLA
     VGFGEATMTT LKRLSGFISA QQIRLVTLSG GVGPYMTGIG QLDAACSVSI MPAPLRASSQ
     EIACTLRNEN SVRDVMLTAQ AADAAIVGIG AINQKDQASI LKSGYITQGE QLMIGRKGAV
     GDILGYFFDA HGEIIPDIKI HNELIGLKLN SLSTIPTVIG VAGGEQKAEA IIAAMRGNYI
     NALVTDQKTA GKIIQIIEK