LST1_HUMAN
ID LST1_HUMAN Reviewed; 97 AA.
AC O00453; B0S8E0; B0S8E1; B0S8E5; O00452; O00454; Q13669; Q2HNT3; Q5HYS9;
AC Q5SP24; Q5STA5; Q5STA6; Q5STA7; Q5STA8; Q5STW6; Q9UJR5; Q9UJR6; Q9UJR7;
AC Q9UJR8; Q9UJS1;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Leukocyte-specific transcript 1 protein;
DE AltName: Full=Protein B144;
GN Name=LST1; Synonyms=B144;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000312|EMBL:AAB86999.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), TISSUE SPECIFICITY, AND
RP INDUCTION BY IFNG.
RC TISSUE=Blood {ECO:0000269|PubMed:7590964};
RX PubMed=7590964; DOI=10.1007/bf00179392;
RA Holzinger I., de Baey A., Messer G., Kick G., Zwierzina H., Weiss E.H.;
RT "Cloning and genomic characterization of LST1: a new gene in the human TNF
RT region.";
RL Immunogenetics 42:315-322(1995).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4), TISSUE SPECIFICITY, AND
RP INDUCTION BY IFNG.
RC TISSUE=Lymphoblast {ECO:0000269|PubMed:9367684};
RX PubMed=9367684; DOI=10.1006/geno.1997.4963;
RA de Baey A., Fellerhoff B., Maier S., Martinozzi S., Weidle U., Weiss E.H.;
RT "Complex expression pattern of the TNF region gene LST1 through
RT differential regulation, initiation, and alternative splicing.";
RL Genomics 45:591-600(1997).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7; 8 AND 9), FUNCTION, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Peripheral blood {ECO:0000269|PubMed:10706707};
RX PubMed=10706707; DOI=10.4049/jimmunol.164.6.3169;
RA Rollinger-Holzinger I., Eibl B., Pauly M., Griesser U., Hentges F.,
RA Auer B., Pall G., Schratzberger P., Niederwieser D., Weiss E.H.,
RA Zwierzina H.;
RT "LST1: a gene with extensive alternative splicing and immunomodulatory
RT function.";
RL J. Immunol. 164:3169-3176(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [5] {ECO:0000305, ECO:0000312|EMBL:BAB63394.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7] {ECO:0000305, ECO:0000312|EMBL:BAB63394.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-93 (ISOFORM 11), AND INDUCTION.
RX PubMed=16362817; DOI=10.1007/s00251-005-0057-2;
RA Mulcahy H., O'rourke K.P., Adams C., Molloy M.G., O'gara F.;
RT "LST1 and NCR3 expression in autoimmune inflammation and in response to
RT IFN-gamma, LPS and microbial infection.";
RL Immunogenetics 57:893-903(2006).
RN [10] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11478849; DOI=10.1006/excr.2001.5290;
RA Raghunathan A., Sivakamasundari R., Wolenski J., Poddar R., Weissman S.M.;
RT "Functional analysis of B144/LST1: a gene in the tumor necrosis factor
RT cluster that induces formation of long filopodia in eukaryotic cells.";
RL Exp. Cell Res. 268:230-244(2001).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Possible role in modulating immune responses. Induces
CC morphological changes including production of filopodia and microspikes
CC when overexpressed in a variety of cell types and may be involved in
CC dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory
CC effect on lymphocyte proliferation. {ECO:0000269|PubMed:10706707,
CC ECO:0000269|PubMed:11478849}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Golgi
CC apparatus membrane; Single-pass membrane protein. Endomembrane system;
CC Single-pass membrane protein. Note=Also detected in a perinuclear
CC region corresponding to the localization of the Golgi apparatus and
CC throughout the cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=13;
CC Comment=Additional isoforms seem to exist.
CC {ECO:0000269|PubMed:10706707};
CC Name=1 {ECO:0000269|PubMed:9367684}; Synonyms=LST1/A
CC {ECO:0000269|PubMed:9367684};
CC IsoId=O00453-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:9367684}; Synonyms=LST1/C
CC {ECO:0000269|PubMed:9367684};
CC IsoId=O00453-2; Sequence=VSP_050578;
CC Name=3 {ECO:0000269|PubMed:7590964}; Synonyms=pLst1
CC {ECO:0000269|PubMed:7590964};
CC IsoId=O00453-3; Sequence=VSP_050579;
CC Name=4 {ECO:0000269|PubMed:9367684}; Synonyms=LST1/E
CC {ECO:0000269|PubMed:9367684};
CC IsoId=O00453-4; Sequence=VSP_050577;
CC Name=5 {ECO:0000269|PubMed:10706707}; Synonyms=LST1/K
CC {ECO:0000269|PubMed:10706707};
CC IsoId=O00453-5; Sequence=VSP_050584;
CC Name=6 {ECO:0000269|PubMed:10706707}; Synonyms=LST1/L
CC {ECO:0000269|PubMed:10706707};
CC IsoId=O00453-6; Sequence=VSP_050583, VSP_050587;
CC Name=7 {ECO:0000269|PubMed:10706707}; Synonyms=LST1/J
CC {ECO:0000269|PubMed:10706707};
CC IsoId=O00453-7; Sequence=VSP_050583, VSP_050586;
CC Name=8 {ECO:0000269|PubMed:10706707}; Synonyms=LST1/M
CC {ECO:0000269|PubMed:10706707};
CC IsoId=O00453-8; Sequence=VSP_050580;
CC Name=9 {ECO:0000269|PubMed:10706707}; Synonyms=LST1/N
CC {ECO:0000269|PubMed:10706707};
CC IsoId=O00453-9; Sequence=VSP_050581, VSP_050582;
CC Name=10;
CC IsoId=O00453-10; Sequence=VSP_050583;
CC Name=11; Synonyms=LST1/P;
CC IsoId=O00453-11; Sequence=VSP_046459;
CC Name=12;
CC IsoId=O00453-12; Sequence=VSP_047367;
CC Name=13;
CC IsoId=O00453-13; Sequence=VSP_050583, VSP_046459;
CC -!- TISSUE SPECIFICITY: Expressed in lung, tonsil, thymus, placenta,
CC kidney, fetal spleen, fetal liver and brain.
CC {ECO:0000269|PubMed:7590964, ECO:0000269|PubMed:9367684}.
CC -!- INDUCTION: By IFNG/IFN-gamma. Up-regulated upon autoimmune and
CC bacterially-induced inflammation. {ECO:0000269|PubMed:16362817,
CC ECO:0000269|PubMed:7590964, ECO:0000269|PubMed:9367684}.
CC -!- SIMILARITY: Belongs to the LST1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX45332.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; U00921; AAB57724.1; -; Genomic_DNA.
DR EMBL; AF000424; AAB86998.1; -; mRNA.
DR EMBL; AF000425; AAB86999.1; -; mRNA.
DR EMBL; AF000426; AAB87000.1; -; mRNA.
DR EMBL; Y18486; CAB59904.1; -; mRNA.
DR EMBL; Y18487; CAB59905.1; -; mRNA.
DR EMBL; Y18488; CAB60038.1; -; mRNA.
DR EMBL; Y18489; CAB59906.1; -; mRNA.
DR EMBL; Y18490; CAB59903.1; -; mRNA.
DR EMBL; AF129756; AAD18090.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63394.1; -; Genomic_DNA.
DR EMBL; AL662801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR942185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03427.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03431.1; -; Genomic_DNA.
DR EMBL; BC103855; AAI03856.1; -; mRNA.
DR EMBL; BC103856; AAI03857.1; -; mRNA.
DR EMBL; AY852266; AAX45332.1; ALT_SEQ; mRNA.
DR CCDS; CCDS43450.2; -. [O00453-1]
DR CCDS; CCDS4705.2; -. [O00453-10]
DR CCDS; CCDS54984.1; -. [O00453-11]
DR CCDS; CCDS54985.1; -. [O00453-12]
DR CCDS; CCDS54986.1; -. [O00453-5]
DR CCDS; CCDS54987.1; -. [O00453-13]
DR RefSeq; NP_001160010.1; NM_001166538.1. [O00453-13]
DR RefSeq; NP_009092.3; NM_007161.3. [O00453-11]
DR RefSeq; NP_995309.2; NM_205837.2. [O00453-12]
DR RefSeq; NP_995310.2; NM_205838.2. [O00453-10]
DR RefSeq; NP_995311.2; NM_205839.2. [O00453-1]
DR RefSeq; NP_995312.2; NM_205840.2. [O00453-5]
DR RefSeq; XP_006715269.1; XM_006715206.3. [O00453-11]
DR RefSeq; XP_006715272.1; XM_006715209.3. [O00453-13]
DR RefSeq; XP_006715273.1; XM_006715210.3. [O00453-5]
DR RefSeq; XP_011513216.1; XM_011514914.2. [O00453-11]
DR AlphaFoldDB; O00453; -.
DR SMR; O00453; -.
DR BioGRID; 113666; 3.
DR IntAct; O00453; 2.
DR STRING; 9606.ENSP00000365261; -.
DR iPTMnet; O00453; -.
DR PhosphoSitePlus; O00453; -.
DR SwissPalm; O00453; -.
DR BioMuta; LST1; -.
DR EPD; O00453; -.
DR jPOST; O00453; -.
DR MassIVE; O00453; -.
DR PeptideAtlas; O00453; -.
DR PRIDE; O00453; -.
DR ProteomicsDB; 47899; -. [O00453-1]
DR ProteomicsDB; 47900; -. [O00453-10]
DR ProteomicsDB; 47901; -. [O00453-2]
DR ProteomicsDB; 47902; -. [O00453-3]
DR ProteomicsDB; 47903; -. [O00453-4]
DR ProteomicsDB; 47904; -. [O00453-5]
DR ProteomicsDB; 47905; -. [O00453-6]
DR ProteomicsDB; 63775; -.
DR ProteomicsDB; 63901; -.
DR TopDownProteomics; O00453-12; -. [O00453-12]
DR Antibodypedia; 27216; 176 antibodies from 26 providers.
DR DNASU; 7940; -.
DR Ensembl; ENST00000303757.12; ENSP00000303649.7; ENSG00000204482.11. [O00453-5]
DR Ensembl; ENST00000339530.8; ENSP00000339201.4; ENSG00000204482.11. [O00453-12]
DR Ensembl; ENST00000376086.7; ENSP00000365254.3; ENSG00000204482.11. [O00453-13]
DR Ensembl; ENST00000376089.6; ENSP00000365257.2; ENSG00000204482.11. [O00453-10]
DR Ensembl; ENST00000376092.7; ENSP00000365260.3; ENSG00000204482.11. [O00453-8]
DR Ensembl; ENST00000376093.6; ENSP00000365261.2; ENSG00000204482.11. [O00453-11]
DR Ensembl; ENST00000376096.5; ENSP00000365264.1; ENSG00000204482.11. [O00453-9]
DR Ensembl; ENST00000376110.7; ENSP00000365278.3; ENSG00000204482.11. [O00453-6]
DR Ensembl; ENST00000383480.6; ENSP00000372972.2; ENSG00000206433.10. [O00453-13]
DR Ensembl; ENST00000383482.2; ENSP00000372974.2; ENSG00000206433.10. [O00453-8]
DR Ensembl; ENST00000383484.6; ENSP00000372976.2; ENSG00000206433.10. [O00453-12]
DR Ensembl; ENST00000383486.6; ENSP00000372978.2; ENSG00000206433.10. [O00453-11]
DR Ensembl; ENST00000400250.5; ENSP00000383109.1; ENSG00000206433.10. [O00453-5]
DR Ensembl; ENST00000400257.5; ENSP00000383116.1; ENSG00000206433.10. [O00453-9]
DR Ensembl; ENST00000400262.5; ENSP00000383121.1; ENSG00000206433.10. [O00453-10]
DR Ensembl; ENST00000400263.5; ENSP00000383122.1; ENSG00000206433.10. [O00453-10]
DR Ensembl; ENST00000400264.5; ENSP00000383123.1; ENSG00000206433.10. [O00453-1]
DR Ensembl; ENST00000400265.5; ENSP00000383124.1; ENSG00000206433.10. [O00453-6]
DR Ensembl; ENST00000411490.5; ENSP00000395409.1; ENSG00000235915.8. [O00453-1]
DR Ensembl; ENST00000412041.5; ENSP00000399411.1; ENSG00000231048.8. [O00453-11]
DR Ensembl; ENST00000412623.1; ENSP00000409229.1; ENSG00000226182.8. [O00453-11]
DR Ensembl; ENST00000413426.5; ENSP00000408876.1; ENSG00000231048.8. [O00453-9]
DR Ensembl; ENST00000414266.5; ENSP00000402707.1; ENSG00000223465.8. [O00453-10]
DR Ensembl; ENST00000415419.5; ENSP00000415143.1; ENSG00000235915.8. [O00453-6]
DR Ensembl; ENST00000415490.5; ENSP00000390658.1; ENSG00000234514.8. [O00453-8]
DR Ensembl; ENST00000415781.5; ENSP00000401655.1; ENSG00000226182.8. [O00453-9]
DR Ensembl; ENST00000417428.5; ENSP00000394614.1; ENSG00000223465.8. [O00453-1]
DR Ensembl; ENST00000418507.6; ENSP00000405900.2; ENSG00000204482.11. [O00453-10]
DR Ensembl; ENST00000420157.5; ENSP00000398700.1; ENSG00000226182.8. [O00453-10]
DR Ensembl; ENST00000420333.5; ENSP00000411547.1; ENSG00000230791.8. [O00453-5]
DR Ensembl; ENST00000420676.5; ENSP00000414246.1; ENSG00000226182.8. [O00453-13]
DR Ensembl; ENST00000420785.5; ENSP00000393345.1; ENSG00000234514.8. [O00453-12]
DR Ensembl; ENST00000420797.5; ENSP00000390587.1; ENSG00000235915.8. [O00453-10]
DR Ensembl; ENST00000422035.5; ENSP00000396431.1; ENSG00000226182.8. [O00453-6]
DR Ensembl; ENST00000422533.5; ENSP00000412627.1; ENSG00000226182.8. [O00453-5]
DR Ensembl; ENST00000423107.6; ENSP00000406438.2; ENSG00000234514.8. [O00453-10]
DR Ensembl; ENST00000423871.5; ENSP00000400069.1; ENSG00000223465.8. [O00453-6]
DR Ensembl; ENST00000425760.5; ENSP00000409698.1; ENSG00000231048.8. [O00453-8]
DR Ensembl; ENST00000426938.5; ENSP00000404051.1; ENSG00000234514.8. [O00453-1]
DR Ensembl; ENST00000427186.5; ENSP00000399439.1; ENSG00000235915.8. [O00453-8]
DR Ensembl; ENST00000427507.6; ENSP00000416283.2; ENSG00000223465.8. [O00453-1]
DR Ensembl; ENST00000428227.5; ENSP00000413526.1; ENSG00000234514.8. [O00453-10]
DR Ensembl; ENST00000428405.5; ENSP00000391963.1; ENSG00000230791.8. [O00453-10]
DR Ensembl; ENST00000428898.5; ENSP00000389694.1; ENSG00000230791.8. [O00453-9]
DR Ensembl; ENST00000429874.5; ENSP00000387560.1; ENSG00000230791.8. [O00453-1]
DR Ensembl; ENST00000429910.5; ENSP00000399063.1; ENSG00000223465.8. [O00453-5]
DR Ensembl; ENST00000430632.5; ENSP00000392949.1; ENSG00000231048.8. [O00453-1]
DR Ensembl; ENST00000430680.5; ENSP00000398918.1; ENSG00000235915.8. [O00453-12]
DR Ensembl; ENST00000430997.5; ENSP00000389795.1; ENSG00000235915.8. [O00453-5]
DR Ensembl; ENST00000432009.6; ENSP00000409433.2; ENSG00000226182.8. [O00453-10]
DR Ensembl; ENST00000432164.5; ENSP00000394834.1; ENSG00000223465.8. [O00453-8]
DR Ensembl; ENST00000433004.5; ENSP00000390430.1; ENSG00000226182.8. [O00453-10]
DR Ensembl; ENST00000433305.5; ENSP00000407417.1; ENSG00000230791.8. [O00453-8]
DR Ensembl; ENST00000433676.6; ENSP00000411866.2; ENSG00000235915.8. [O00453-10]
DR Ensembl; ENST00000434314.6; ENSP00000414173.2; ENSG00000226182.8. [O00453-1]
DR Ensembl; ENST00000436037.5; ENSP00000398685.1; ENSG00000234514.8. [O00453-11]
DR Ensembl; ENST00000436185.5; ENSP00000396579.1; ENSG00000235915.8. [O00453-10]
DR Ensembl; ENST00000437137.6; ENSP00000412276.2; ENSG00000231048.8. [O00453-1]
DR Ensembl; ENST00000437436.5; ENSP00000394891.1; ENSG00000231048.8. [O00453-6]
DR Ensembl; ENST00000437812.5; ENSP00000396179.1; ENSG00000223465.8. [O00453-11]
DR Ensembl; ENST00000438075.7; ENSP00000391929.3; ENSG00000204482.11. [O00453-1]
DR Ensembl; ENST00000438335.5; ENSP00000403097.1; ENSG00000235915.8. [O00453-11]
DR Ensembl; ENST00000438349.5; ENSP00000391057.1; ENSG00000234514.8. [O00453-6]
DR Ensembl; ENST00000438381.5; ENSP00000393282.1; ENSG00000230791.8. [O00453-12]
DR Ensembl; ENST00000440242.5; ENSP00000394815.1; ENSG00000223465.8. [O00453-13]
DR Ensembl; ENST00000440253.5; ENSP00000396235.1; ENSG00000223465.8. [O00453-10]
DR Ensembl; ENST00000440323.5; ENSP00000414744.1; ENSG00000231048.8. [O00453-10]
DR Ensembl; ENST00000440328.5; ENSP00000401516.1; ENSG00000226182.8. [O00453-8]
DR Ensembl; ENST00000442052.5; ENSP00000399474.1; ENSG00000226182.8. [O00453-12]
DR Ensembl; ENST00000443340.6; ENSP00000396533.2; ENSG00000206433.10. [O00453-1]
DR Ensembl; ENST00000443655.5; ENSP00000411961.1; ENSG00000231048.8. [O00453-5]
DR Ensembl; ENST00000443741.6; ENSP00000388956.2; ENSG00000235915.8. [O00453-1]
DR Ensembl; ENST00000446239.5; ENSP00000402873.1; ENSG00000230791.8. [O00453-6]
DR Ensembl; ENST00000447141.5; ENSP00000397826.1; ENSG00000235915.8. [O00453-9]
DR Ensembl; ENST00000447391.5; ENSP00000411087.1; ENSG00000230791.8. [O00453-10]
DR Ensembl; ENST00000448236.5; ENSP00000406455.1; ENSG00000230791.8. [O00453-11]
DR Ensembl; ENST00000448441.6; ENSP00000409008.2; ENSG00000206433.10. [O00453-10]
DR Ensembl; ENST00000449236.5; ENSP00000391420.1; ENSG00000231048.8. [O00453-10]
DR Ensembl; ENST00000449273.5; ENSP00000415623.1; ENSG00000234514.8. [O00453-5]
DR Ensembl; ENST00000450291.5; ENSP00000404500.1; ENSG00000230791.8. [O00453-13]
DR Ensembl; ENST00000450425.6; ENSP00000415168.2; ENSG00000223465.8. [O00453-10]
DR Ensembl; ENST00000451641.5; ENSP00000406625.1; ENSG00000223465.8. [O00453-12]
DR Ensembl; ENST00000451922.5; ENSP00000401567.1; ENSG00000231048.8. [O00453-13]
DR Ensembl; ENST00000452169.5; ENSP00000416808.1; ENSG00000231048.8. [O00453-12]
DR Ensembl; ENST00000453995.6; ENSP00000409163.2; ENSG00000230791.8. [O00453-1]
DR Ensembl; ENST00000454168.5; ENSP00000396004.1; ENSG00000234514.8. [O00453-13]
DR Ensembl; ENST00000455003.5; ENSP00000396181.1; ENSG00000226182.8. [O00453-1]
DR Ensembl; ENST00000455052.5; ENSP00000398228.1; ENSG00000234514.8. [O00453-10]
DR Ensembl; ENST00000455426.6; ENSP00000398780.2; ENSG00000231048.8. [O00453-10]
DR Ensembl; ENST00000455493.5; ENSP00000401650.1; ENSG00000223465.8. [O00453-9]
DR Ensembl; ENST00000455655.6; ENSP00000415526.2; ENSG00000230791.8. [O00453-10]
DR Ensembl; ENST00000455901.6; ENSP00000396378.2; ENSG00000234514.8. [O00453-1]
DR Ensembl; ENST00000457549.5; ENSP00000390885.1; ENSG00000235915.8. [O00453-13]
DR Ensembl; ENST00000458456.5; ENSP00000405920.1; ENSG00000234514.8. [O00453-9]
DR GeneID; 7940; -.
DR KEGG; hsa:7940; -.
DR MANE-Select; ENST00000438075.7; ENSP00000391929.3; NM_205839.3; NP_995311.2.
DR UCSC; uc021yus.1; human. [O00453-1]
DR CTD; 7940; -.
DR DisGeNET; 7940; -.
DR GeneCards; LST1; -.
DR HGNC; HGNC:14189; LST1.
DR HPA; ENSG00000204482; Group enriched (bone marrow, lung, lymphoid tissue).
DR MIM; 109170; gene.
DR neXtProt; NX_O00453; -.
DR OpenTargets; ENSG00000204482; -.
DR PharmGKB; PA37856; -.
DR VEuPathDB; HostDB:ENSG00000204482; -.
DR eggNOG; ENOG502TDBU; Eukaryota.
DR GeneTree; ENSGT00730000112003; -.
DR HOGENOM; CLU_166968_0_0_1; -.
DR InParanoid; O00453; -.
DR OMA; FICLCRG; -.
DR OrthoDB; 1605415at2759; -.
DR PhylomeDB; O00453; -.
DR TreeFam; TF338533; -.
DR PathwayCommons; O00453; -.
DR SignaLink; O00453; -.
DR BioGRID-ORCS; 7940; 109 hits in 1063 CRISPR screens.
DR ChiTaRS; LST1; human.
DR GeneWiki; LST1; -.
DR GenomeRNAi; 7940; -.
DR Pharos; O00453; Tbio.
DR PRO; PR:O00453; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O00453; protein.
DR Bgee; ENSG00000204482; Expressed in granulocyte and 171 other tissues.
DR ExpressionAtlas; O00453; baseline and differential.
DR Genevisible; O00453; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005794; C:Golgi apparatus; NAS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0009653; P:anatomical structure morphogenesis; NAS:UniProtKB.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0016358; P:dendrite development; IDA:UniProtKB.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IDA:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR007775; Leukocyte-sp_tscrpt_1_LST1.
DR PANTHER; PTHR15452; PTHR15452; 1.
DR Pfam; PF05083; LST1; 1.
DR PIRSF; PIRSF037638; Leukocyte-sp_tscrpt_1_LST1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell shape; Golgi apparatus; Immunity; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="Leukocyte-specific transcript 1 protein"
FT /id="PRO_0000084507"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 59..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VAR_SEQ 1..46
FT /note="MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWA -> MT
FT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:9367684"
FT /id="VSP_050577"
FT VAR_SEQ 1..45
FT /note="MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSW -> MIY
FT VSTGAWGWAGSCFWQWSFCPPACVGCIEEHLLSWSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9367684"
FT /id="VSP_050578"
FT VAR_SEQ 1..45
FT /note="MLSRNDDICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSW -> MIY
FT VSTGAWGWAGSCFWQWSFCPPACVGCIEEE (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_050579"
FT VAR_SEQ 7..97
FT /note="DICIYGGLGLGGLLLLAVVLLSACLCWLHRRVKRLERSWAQGSSEQELHYAS
FT LQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT -> APSVLVPGPGLLRAGT
FT PLCISAEAASAQQ (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:10706707"
FT /id="VSP_050580"
FT VAR_SEQ 7..37
FT /note="Missing (in isoform 6, isoform 7, isoform 10 and
FT isoform 13)"
FT /evidence="ECO:0000303|PubMed:10706707,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_050583"
FT VAR_SEQ 7..13
FT /note="DICIYGG -> EAASAQQ (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:10706707"
FT /id="VSP_050581"
FT VAR_SEQ 14..97
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:10706707"
FT /id="VSP_050582"
FT VAR_SEQ 38..97
FT /note="VKRLERSWAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYA
FT CIAENKPT -> APSVLVPGPGLLRAGTPLCISAEAASAQQ (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_047367"
FT VAR_SEQ 38..97
FT /note="VKRLERSWAQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYA
FT CIAENKPT -> GPGLLRAGTPLCISAEAASAQQ (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10706707"
FT /id="VSP_050584"
FT VAR_SEQ 45
FT /note="W -> WHLLSWSQ (in isoform 11 and isoform 13)"
FT /evidence="ECO:0000303|PubMed:16362817"
FT /id="VSP_046459"
FT VAR_SEQ 46..97
FT /note="AQGSSEQELHYASLQRLPVPSSEGPDLRGRDKRGTKEDPRADYACIAENKPT
FT -> HLSVLVPGPGLLRAGTPLCISAEAASAQQ (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:10706707"
FT /id="VSP_050586"
FT VAR_SEQ 46..60
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:10706707"
FT /id="VSP_050587"
FT CONFLICT 21
FT /note="L -> P (in Ref. 9; AAX45332)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="A -> T (in Ref. 2; AAB86999)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 97 AA; 10792 MW; AA03C77B5787B524 CRC64;
MLSRNDDICI YGGLGLGGLL LLAVVLLSAC LCWLHRRVKR LERSWAQGSS EQELHYASLQ
RLPVPSSEGP DLRGRDKRGT KEDPRADYAC IAENKPT
