ID   LST1_MACMU              Reviewed;          93 AA.
AC   Q5TM23;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Leukocyte-specific transcript 1 protein;
GN   Name=LST1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15269276; DOI=10.1093/molbev/msh216;
RA   Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT   "Rhesus macaque class I duplicon structures, organization, and evolution
RT   within the alpha block of the major histocompatibility complex.";
RL   Mol. Biol. Evol. 21:2079-2091(2004).
CC   -!- FUNCTION: Possible role in modulating immune responses. Has an
CC       inhibitory effect on lymphocyte proliferation. Induces morphological
CC       changes including production of filopodia and microspikes when
CC       overexpressed in a variety of cell types and may be involved in
CC       dendritic cell maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass membrane protein {ECO:0000250}. Endomembrane system {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Note=Also detected in a
CC       perinuclear region corresponding to the localization of the Golgi
CC       apparatus and throughout the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LST1 family. {ECO:0000305}.
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DR   EMBL; AB128049; BAD69722.1; -; Genomic_DNA.
DR   RefSeq; NP_001108434.1; NM_001114962.1.
DR   AlphaFoldDB; Q5TM23; -.
DR   HOGENOM; CLU_2460313_0_0_1; -.
DR   InParanoid; Q5TM23; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR   GO; GO:0016358; P:dendrite development; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR007775; Leukocyte-sp_tscrpt_1_LST1.
DR   PANTHER; PTHR15452; PTHR15452; 1.
DR   Pfam; PF05083; LST1; 1.
PE   3: Inferred from homology;
KW   Cell shape; Golgi apparatus; Immunity; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..93
FT                   /note="Leukocyte-specific transcript 1 protein"
FT                   /id="PRO_0000084508"
FT   TRANSMEM        14..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          57..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O00453"
SQ   SEQUENCE   93 AA;  10413 MW;  6CEE73F4F6F35E64 CRC64;
     MIHVYTSTGA WGWAGSCCWL WSFCPPACIG CIEEHLLSWP QVQGSSEQEI HYASLQRLPV
     SSSEGPDLRD RDKRGTKEDP RADYACIAEN KPT