LST1_MOUSE
ID LST1_MOUSE Reviewed; 95 AA.
AC O08843; O08844; Q9Z1H3; Q9Z1R0;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Leukocyte-specific transcript 1 protein;
DE AltName: Full=Protein B144;
GN Name=Lst1; Synonyms=B144;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAB87001.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=B-cell {ECO:0000269|PubMed:3117682};
RX PubMed=3117682; DOI=10.1007/bf00343709;
RA Tsuge I., Shen F.-W., Steinmetz M., Boyse E.A.;
RT "A gene in the H-2S:H-2D interval of the major histocompatibility complex
RT which is transcribed in B cells and macrophages.";
RL Immunogenetics 26:378-380(1987).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=BALB/cJ {ECO:0000269|PubMed:9367684};
RC TISSUE=Macrophage {ECO:0000269|PubMed:9367684};
RX PubMed=9367684; DOI=10.1006/geno.1997.4963;
RA de Baey A., Fellerhoff B., Maier S., Martinozzi S., Weidle U., Weiss E.H.;
RT "Complex expression pattern of the TNF region gene LST1 through
RT differential regulation, initiation, and alternative splicing.";
RL Genomics 45:591-600(1997).
RN [3] {ECO:0000312|EMBL:AAC82482.1}
RP NUCLEOTIDE SEQUENCE.
RA Rowen L., Qin S., Madan A., Abbasi N., James R., Dickhoff R., Shaffer T.,
RA Ratcliffe A., Loretz C., Lasky S., Hood L.;
RT "Sequence of the mouse major histocompatibility class III region.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11478849; DOI=10.1006/excr.2001.5290;
RA Raghunathan A., Sivakamasundari R., Wolenski J., Poddar R., Weissman S.M.;
RT "Functional analysis of B144/LST1: a gene in the tumor necrosis factor
RT cluster that induces formation of long filopodia in eukaryotic cells.";
RL Exp. Cell Res. 268:230-244(2001).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- FUNCTION: Possible role in modulating immune responses. Has an
CC inhibitory effect on lymphocyte proliferation. Induces morphological
CC changes including production of filopodia and microspikes when
CC overexpressed in a variety of cell types and may be involved in
CC dendritic cell maturation. {ECO:0000250|UniProtKB:O00453,
CC ECO:0000269|PubMed:11478849, ECO:0000303|PubMed:11478849}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}. Note=Also detected in a perinuclear region
CC corresponding to the localization of the Golgi apparatus and throughout
CC the cytoplasm. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:9367684}; Synonyms=m17r
CC {ECO:0000269|PubMed:9367684};
CC IsoId=O08843-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:9367684}; Synonyms=m21r
CC {ECO:0000269|PubMed:9367684};
CC IsoId=O08843-2; Sequence=VSP_050588;
CC -!- TISSUE SPECIFICITY: Expressed in spleen and at lower levels in thymus
CC and liver. {ECO:0000269|PubMed:11478849}.
CC -!- SIMILARITY: Belongs to the LST1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA37273.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAC82482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; M18187; AAA37273.1; ALT_FRAME; mRNA.
DR EMBL; AF000427; AAB87001.1; -; mRNA.
DR EMBL; AF000428; AAB87002.1; -; mRNA.
DR EMBL; AF109719; AAC82482.1; ALT_SEQ; Genomic_DNA.
DR PIR; I49515; I49515.
DR AlphaFoldDB; O08843; -.
DR SMR; O08843; -.
DR STRING; 10090.ENSMUSP00000094949; -.
DR iPTMnet; O08843; -.
DR PhosphoSitePlus; O08843; -.
DR SwissPalm; O08843; -.
DR jPOST; O08843; -.
DR MaxQB; O08843; -.
DR PaxDb; O08843; -.
DR PRIDE; O08843; -.
DR ProteomicsDB; 290182; -. [O08843-1]
DR ProteomicsDB; 290183; -. [O08843-2]
DR MGI; MGI:1096324; Lst1.
DR eggNOG; ENOG502TDBU; Eukaryota.
DR InParanoid; O08843; -.
DR PhylomeDB; O08843; -.
DR ChiTaRS; Lst1; mouse.
DR PRO; PR:O08843; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O08843; protein.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0016358; P:dendrite development; IDA:UniProtKB.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; ISS:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR007775; Leukocyte-sp_tscrpt_1_LST1.
DR PANTHER; PTHR15452; PTHR15452; 1.
DR Pfam; PF05083; LST1; 1.
DR PIRSF; PIRSF037638; Leukocyte-sp_tscrpt_1_LST1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell shape; Immunity; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..95
FT /note="Leukocyte-specific transcript 1 protein"
FT /id="PRO_0000084509"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00453"
FT VAR_SEQ 53..66
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:3117682,
FT ECO:0000303|PubMed:9367684"
FT /id="VSP_050588"
FT CONFLICT 15
FT /note="H -> D (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 19
FT /note="Y -> N (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="G -> R (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 53..54
FT /note="Missing (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 95 AA; 10325 MW; 7B222EC72CF73C2C CRC64;
MSDDNGSGNN CTTNHFLLYG SLGLGGLLLL LVIILFICLC GFSQRVKRLE RNAQVSGQEP
HYASLQQLPV SSSDITDMKE DLSTDYACIA RSTPT
