LST2_CULQU
ID LST2_CULQU Reviewed; 907 AA.
AC B0WAQ0;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Lateral signaling target protein 2 homolog;
GN ORFNames=CPIJ004116;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR)
CC signaling. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lst-2 family. {ECO:0000305}.
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DR EMBL; DS231874; EDS41691.1; -; Genomic_DNA.
DR RefSeq; XP_001845784.1; XM_001845732.1.
DR AlphaFoldDB; B0WAQ0; -.
DR SMR; B0WAQ0; -.
DR STRING; 7176.CPIJ004116-PA; -.
DR GeneID; 6035645; -.
DR KEGG; cqu:CpipJ_CPIJ004116; -.
DR VEuPathDB; VectorBase:CPIJ004116; -.
DR VEuPathDB; VectorBase:CQUJHB012925; -.
DR eggNOG; KOG1818; Eukaryota.
DR eggNOG; KOG1819; Eukaryota.
DR HOGENOM; CLU_007360_1_0_1; -.
DR InParanoid; B0WAQ0; -.
DR OMA; DAPRCMA; -.
DR OrthoDB; 451347at2759; -.
DR PhylomeDB; B0WAQ0; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..907
FT /note="Lateral signaling target protein 2 homolog"
FT /id="PRO_0000378961"
FT ZN_FING 845..905
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT REGION 339..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..393
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..516
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..548
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 851
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 854
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 867
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 870
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 875
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 878
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 897
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 900
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
SQ SEQUENCE 907 AA; 98062 MW; FFED7BBD2C70F629 CRC64;
MLVGADDKSL LARFYHADRA LTAVASELDS FDGRAEPVRC TRLVGRLRQG QDRVLAITNQ
IMDELLGEDR AARAFRAKFP EEVLQESLAG QLWFGAECLA AGSSIMNREV ESATMRPLAK
AVTKSLDNVR NLLREQCLRN NTPNSLTLRL DVNDAATEQL YESLKIFDRL FAEFELLYVS
AMVQVKSKQE YEMQELICVL FSETLQRALK VGLLEQEQVD SYDPALMFSI PRLAIVAGLV
IFKEGPLNMD QPADDISEMF RPFRKLLIKM RDLLRTLTKH ELYQLEKLLC TNEEISLKEQ
QIICDGNEIV GGGQSPSAAP NPARDDTVVI VTTSATVNSS DNLRGQEPQE DISSFYTSNN
RRTVDSEPNE DDDVSESNDE DEDEGEEVDE DDPANILKDA LVTSDCASGY LIPNTNFGNL
LQTNEAPLTD SFIATDEELK LASGAASSHA RIEQILSESN QKLTDSGLGT ANPSLDHSPE
LETERPVTSS HPIAQSSSSS SEEEGEVDEY DEDDSESTLC EPKPHHTKHQ RRHRHHHHHH
RKHYSKHRSS AAGSAGTSGT TCSAAERQIS SCDTSPSSGG LPSECGSSTS GGSSGNSSGG
SGDADAAQEV AMAIRAAGRI KFKTTENLLH RLFVCIAGVA DQLQTNFAAD LRQMLKSVFV
INSSPPEPED PPEPAANSTD KPKEPDPADL FEFRASEQDV ITNSGGSSQS IYSAEEVNAE
DPHDSVFGSP PGGASPVRAS SAPRTMMTTA ASSENGSVTV NVSVSVVTAG SGGSGSGSSR
SSQERSVSLS ETSIVVDGSG GNTEGTALLV PRESTPKSVQ SEQSGQRGMM EERRMPEAPP
RWIPDGDAPR CMACASSFTP FRRRHHCRNC GGVFCGGCSS ASAPLPKYGL TKAVRVCREC
FVREVGV
