LST2_DROGR
ID LST2_DROGR Reviewed; 1115 AA.
AC B4JHI7;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Lateral signaling target protein 2 homolog;
GN ORFNames=GH18624;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR)
CC signaling. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lst-2 family. {ECO:0000305}.
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DR EMBL; CH916369; EDV92814.1; -; Genomic_DNA.
DR RefSeq; XP_001989752.1; XM_001989716.1.
DR AlphaFoldDB; B4JHI7; -.
DR SMR; B4JHI7; -.
DR STRING; 7222.FBpp0152530; -.
DR EnsemblMetazoa; FBtr0154038; FBpp0152530; FBgn0126091.
DR GeneID; 6563666; -.
DR KEGG; dgr:6563666; -.
DR eggNOG; KOG1819; Eukaryota.
DR HOGENOM; CLU_007360_1_1_1; -.
DR InParanoid; B4JHI7; -.
DR OMA; DAPRCMA; -.
DR OrthoDB; 451347at2759; -.
DR PhylomeDB; B4JHI7; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1115
FT /note="Lateral signaling target protein 2 homolog"
FT /id="PRO_0000378964"
FT ZN_FING 1025..1085
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT REGION 308..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..488
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..656
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..702
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1031
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1034
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1047
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1050
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1055
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1058
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1077
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 1080
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT MOD_RES 603
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 604
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 908
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1115 AA; 122723 MW; 181E530ABF63B6D1 CRC64;
MDTFRKWLNK PKADDKSLLA RFYHADRSLT AVASELDSFD GRAEPDRCTR LVSRLRQNQD
KVLAITNMIM EELLGEDRDP RAFRAKFPEE VLQENLAGQL WFGAECLAAG SSILNRESES
KEMRPLAQAV TKSLGHVRVL LRDQCLRNNV PNSKTLHLDF NDSNTEQLYE SLKIFDHLFA
EFELSYVSAM VQVKSRHEYE MQQWIGVLFS ETLQRSLKVG LLDQDMVDAF DPGLMFSIPR
LAIVAGLVVY AKGPLNMDMP GDQLSEMFRP FRTILIKIRD LLRNLSKQEL YQLEKLLCTN
EDINTKVPLG SSSIEAPSPE HNNSSSTTNT SNNNNNNTNN NNSSSGSDCT NNDKTGTTTN
THKPVERLVD HRNNNTTNSQ QTSSCSVNAA ATTPATSSRT RTPPSILSPS AGSTPTASPA
PSPTPSHSIA STSSAATTST NSPAHWSDYD DDDEDDDDDD VHADVEEDED ESGILDSDEH
DLNDDSDSEV DEFFEAQLKA IVAAVDCAPG YLIPDCASGY LISNTNLGNL LQPQQVPLTD
NFVASEDDEL GNPTAVDQQQ QPQQQLEHHQ QQLQQQQHTE DEPSTSAAML AARRTLQRLR
LPSSSSDNEP SSNNQQMTIK SPSEQTTTRS SSNRHRHHSH HHHHHHHSHH HHHHQPTAAV
AVAAAQDEQH NNNQPHSHSH SSSHHHHHNH QSHSHPHRAN RSTRKRCSQE HCETITTTKT
TSGGEQQTED SLDSSTASSL SDDVSLAMRN TTARLKFKST ENLLHRLFVC IAGVADQLQT
NFASDLRQIL RSVFLMNMSS AQEDIDIPEK TKESELFEFR ASENDVIQES AGSNQSIYSA
EEVNPELDNV FNTNTGTNGA RHSAGATMQR NNTIDLATVQ SSNSGNSSSS NSSSSSSAAR
SHVARSRSLG DHDQASTSSS QQQQRELQLQ LQQQQQQQAQ MQQQLQRHRN NSVGSNSPSS
ASSTSSNSEH NSPVSTRSGS RRRLPSNTTT TLSTSIGTAA TTPTGATTTG VTTTTTMSPP
AWIPDGKAPR CMSCQTPFTV VRRRHHCRNC GGVFCGVCSN ASAPLPKYGL TKAVRVCREC
FMREVRQSHS HGQSQSQIHS PTQQAGGRPQ AASAS
