LST2_DROPE
ID LST2_DROPE Reviewed; 1009 AA.
AC B4G2G5;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Lateral signaling target protein 2 homolog;
GN ORFNames=GL23610;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR)
CC signaling. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lst-2 family. {ECO:0000305}.
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DR EMBL; CH479179; EDW24010.1; -; Genomic_DNA.
DR RefSeq; XP_002013024.1; XM_002012988.1.
DR AlphaFoldDB; B4G2G5; -.
DR SMR; B4G2G5; -.
DR STRING; 7234.FBpp0187717; -.
DR EnsemblMetazoa; FBtr0189225; FBpp0187717; FBgn0161200.
DR eggNOG; KOG1819; Eukaryota.
DR HOGENOM; CLU_007360_1_0_1; -.
DR OMA; DAPRCMA; -.
DR PhylomeDB; B4G2G5; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1009
FT /note="Lateral signaling target protein 2 homolog"
FT /id="PRO_0000378967"
FT ZN_FING 917..977
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT REGION 313..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..459
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..623
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 923
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 926
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 939
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 942
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 947
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 950
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 969
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 972
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT MOD_RES 541
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 807
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1009 AA; 112106 MW; 50D49676EE714A19 CRC64;
MICCEIQQKS HKKNKPQPDD KSLLARFFHA DRSLTAVASE LDSFDGRAEP DRCSRLVSRL
RQNQDKVLSI TNLIMEELLG EDRDPRAFRA KFPEEVLQEN LAGQLWFGAE CLAAGSSIMN
REVESKEMRP LAQAVTKSLG NVRVLLRDQC LRNNVPNSKT LHLDLNDYTT EQLYESLKIF
DRLFAEFELS YVSAMVQVKS RHEYEMQQWI GVLFSETLQR ALKIGLLDQD MVDAFDPGLM
FSIPRLAIVA GLVVYAKGPL DMDMPGDQLS EMFRPFRTIL IKIRDLLRNL NNQELYQLEK
LLCTNEDINT KVPVGSSSIE APTPEHSSTP TTSSNNNNNN KSSSSSSGTG SGSGAGTVER
LVDQRNNNNN QQNSNESTTL PPRSPSMLSL SASSTPTASP APSPTPSHSI ASTTSSAASS
NSTHPPADWS DGDDEDEDEE EDEEEDELED TEDDTDEEQL LKDIVAADCA SGYLIPNTNL
GNLLQPQQVP LTDNFVASED DDEYGTGDQQ QEQPQQQGHR KEDEEEPSTS AALQRLRLAS
SDDSEPHRDQ GETIKSTEEQ EQQQQQQEQQ TLQSSRQRHS HSHSHSHRHH HRHHHHHHHS
THQQQLQHQP HHHQPHPHRL TRSGRKRCSM EAAVEVEQQE QGLASGDTSA ASSLSDDVSL
AMRNTTARLK FNTENLLHRL FVCIAGVADQ LQTNFASDLR QILRSVFLMN MSSVEEEQIE
IPEKTKESEL FEFRASENDV IQESAGSNQS IYSAEEVNPE LDNVFSAGSR HSAGATMQRN
NTIDNPSSSN TSSSSATTRN HVTRSRSLGD QETIARSMPA PVHQQEQEMQ QQQDHQQQQH
QHQVQVQLQR QRNNSVGSNT PSSASSTSSS SEQNSPVSTR SGSSRRRLQS NNETQMPSST
STATAAATLA PPAWIPDGKA PRCMSCQTPF TAFRRRHHCR NCGGVFCGVC SNATAPLPKY
GLTKAVRVCR DCYVREVQVR SSSTTTSVSV NVGVQMQSQA GRVQTATAS
