LST2_DROSE
ID LST2_DROSE Reviewed; 975 AA.
AC B4IC49;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Lateral signaling target protein 2 homolog;
GN ORFNames=GM10129;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR)
CC signaling. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lst-2 family. {ECO:0000305}.
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DR EMBL; CH480828; EDW45207.1; -; Genomic_DNA.
DR RefSeq; XP_002041469.1; XM_002041433.1.
DR AlphaFoldDB; B4IC49; -.
DR SMR; B4IC49; -.
DR STRING; 7238.B4IC49; -.
DR EnsemblMetazoa; FBtr0193114; FBpp0191606; FBgn0165080.
DR HOGENOM; CLU_007360_1_0_1; -.
DR OMA; DAPRCMA; -.
DR PhylomeDB; B4IC49; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..975
FT /note="Lateral signaling target protein 2 homolog"
FT /id="PRO_0000378968"
FT ZN_FING 895..955
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT REGION 299..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..455
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..598
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 901
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 904
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 917
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 920
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 925
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 928
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 947
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 950
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 541
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 796
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 975 AA; 106909 MW; 240390DBDE6984D1 CRC64;
MQSADDKSLL ARFFHADRSL TAVASELDSF DGRAEPDRCT RLVSRLRQNQ DKVLAITNLI
MEELLGEDRD PRAFRAKFPE EVLQENLAGQ LWFGAECLAA GSSIMNRESE SKEMRPLAQA
VTKSLGNVRV LLRDQCLKNN VPNSKTLHLD LNDSTTEQLY ESLKIFDRLF AEFELSYVSA
MVQVKSRHEY EMQQWIGVLF SETLQRALKI GLLDQEMVDA FDPGLMFSIP RLAIVAGLVV
YAKGPLNMDM PGDQLSEMFR PFRTILIKIR DLLRNLNNQE LYQLEKLLCT NEDINTKVPL
GSSSIEAPSP EHSSHPTTSS TQNNNNSSNN NHSSSSTNTT STTITTAGTT NTHRTVERLV
DQRNNNHNSN SNSSSNPTVE GATLRSPSML SLSTTSTPTA SPTPSPTPSH SIASTSSAAT
SSTNPPADWS DGDDEDEDDD DIDVDEEDPE SSDDGTDEEQ LLKDIVAADC ASGYLIPNTN
LGNLLQPQEV PLTDNFVASE DDEYGTAEQQ GHQGLEEEEP STSAAMLAAT RTLQRLRLPS
SDNEPLAEPT TIKASEEHMQ QPSGRHHRHH QSHHHHHHHR HSHQHQHRQP HPHRTTRSGR
KRCSLEAADP ETIQPEREQN LASGDTSAAS SLSDDVSLAM RNTTARLKFK STENLLHRLF
VCIAGVADQL QTNFASDLRQ ILRSVFLMNM SAAQEDIDIP EKTKESELFE FRASENDVIQ
ESAGSNQSIY SAEEVNPELD NVFSAGGGNQ ATGQRHSAGA SMQRNNTIDL ASQPGEGSPS
GATTTTSRSH VTRSRSLGDQ EAASSATSST AQLRQLEQQQ QQQQLQIQLQ RQRNNSVGSN
TPSSASSTSS SSEQNSPVSA RSGSRRRLQS NNETQMPSSA TSTSATLSPP AWIPDGKAPR
CMACQTPFTA FRRRHHCRNC GGVFCGVCSN ASAPLPKYGL TKAVRVCRDC YVREVRSGMG
VQGVQSVQSV QASAS
