ID   LST4_CANGA              Reviewed;         840 AA.
AC   Q6FJ91;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Protein LST4;
GN   Name=LST4; OrderedLocusNames=CAGL0M08228g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in extracellular amino acid uptake. Required for the
CC       protein trafficking from the Golgi to the plasma membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LST4 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62679.1; -; Genomic_DNA.
DR   RefSeq; XP_449703.1; XM_449703.1.
DR   AlphaFoldDB; Q6FJ91; -.
DR   SMR; Q6FJ91; -.
DR   STRING; 5478.XP_449703.1; -.
DR   EnsemblFungi; CAG62679; CAG62679; CAGL0M08228g.
DR   GeneID; 2891262; -.
DR   KEGG; cgr:CAGL0M08228g; -.
DR   CGD; CAL0137017; CAGL0M08228g.
DR   VEuPathDB; FungiDB:CAGL0M08228g; -.
DR   eggNOG; ENOG502QPJF; Eukaryota.
DR   HOGENOM; CLU_010482_0_0_1; -.
DR   InParanoid; Q6FJ91; -.
DR   OMA; NMVVANK; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:1990877; C:FNIP-folliculin RagC/D GAP; IEA:EnsemblFungi.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:EnsemblFungi.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR041153; Longin_2.
DR   Pfam; PF18639; Longin_2; 1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..840
FT                   /note="Protein LST4"
FT                   /id="PRO_0000324405"
FT   DOMAIN          34..223
FT                   /note="uDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   DOMAIN          231..723
FT                   /note="cDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   DOMAIN          731..836
FT                   /note="dDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   REGION          314..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          752..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..767
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   840 AA;  94150 MW;  53469A6AD21A6095 CRC64;
     MGERFEGLEN LNDECKVKLF GCRMRAPGSG TGGHESIEYR LLILEENAEM VCRQRYRTIL
     DYSSRGHGSM GLKHDEMTNG NVSAPFITAS ELRQYIYGSP IRSKTRVTED KFRIIPNSRQ
     LLITRVFYPR RTSMNLHGTF PKNYQSSDRR VSITMCLPSY LLADISDSWA DIDGWLTQTE
     RHLMATSFHV VETQDNFVTL VNKLLIPALR SCHEIPRLFL YPQDNIDFIH TWFKDVFNWI
     ELKEGTKLSF LPFLIAKTLI EYRDDPQESE CHRIVITSGN LVIANKLVFI LGGLLKPRYD
     GEMKIMITPV STPTPSNHLM PPSMNGSNES SYHSSSNSHT PSKLKIPATI NEHRPSRPRY
     SSTENIHVQS RTMDIPIVKS DQSPFSTSRG WKIPSSYRSA TSSVSISSDE SLAEVIQPSS
     LKSTTSIPFQ NFSSSLSNQL YSSSYGSWFN GSITGSFTNS NPLSNGTSNM ATFSSSFKKN
     NISSIFQSNS PTAGTDSWER PENNTGLNPN ITLQRTASNS SLRHMLTPYQ QQLISPSTNS
     EYDEYPWFGA TNNAGGATVG TSSETVGSQQ PVLLQGAHMD TTTLLDSIRT SNNNGAYTFP
     LKNVGFDRDC SSLDHHKLLT SCFEEIFEGD IDANKVTTMV PCSDIAVHIH SKQEDSEGVT
     SHPRVVIDVD IPGTTISKYP EELLPRYTMY LSHFNPFFKL QAIPATNEIE NKIVHGLKRD
     FISEKCDVSK TLFISMRSRS IKEIVVRKTT SINTPSNSSN QDPRNKSKGS MLKQKIKKVF
     SNGTCTGRVT PVLNNCVAFV EAALMSAMSL YSDPTIDKKY RDERILKIFL AVAHYNVDEV