ID   LST4_VANPO              Reviewed;         797 AA.
AC   A7TFI4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Protein LST4;
GN   Name=LST4; ORFNames=Kpol_2002p69;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Involved in extracellular amino acid uptake. Required for the
CC       protein trafficking from the Golgi to the plasma membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LST4 family. {ECO:0000305}.
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DR   EMBL; DS480383; EDO18998.1; -; Genomic_DNA.
DR   RefSeq; XP_001646856.1; XM_001646806.1.
DR   AlphaFoldDB; A7TFI4; -.
DR   SMR; A7TFI4; -.
DR   STRING; 436907.A7TFI4; -.
DR   EnsemblFungi; EDO18998; EDO18998; Kpol_2002p69.
DR   GeneID; 5547324; -.
DR   KEGG; vpo:Kpol_2002p69; -.
DR   eggNOG; ENOG502QPJF; Eukaryota.
DR   HOGENOM; CLU_010482_0_0_1; -.
DR   InParanoid; A7TFI4; -.
DR   OMA; NMVVANK; -.
DR   OrthoDB; 551913at2759; -.
DR   PhylomeDB; A7TFI4; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR041153; Longin_2.
DR   Pfam; PF18639; Longin_2; 1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..797
FT                   /note="Protein LST4"
FT                   /id="PRO_0000324407"
FT   DOMAIN          98..285
FT                   /note="uDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   DOMAIN          293..683
FT                   /note="cDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   DOMAIN          690..767
FT                   /note="dDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   REGION          16..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   797 AA;  89531 MW;  3D6CD404DBDCD73A CRC64;
     MLANLFGKNG LNGSTASLSD SDSGSSSQYN SKPSSQYGSP TSINFKDDTS SILRPISGNI
     LDHMSDDLKS KLFATKDLIS DISLAYYDPK STNSNINISP DSFRLLLTEE TGQMVCRNNY
     RVVLDYVTPK GSYIEQIRPS ELKEYIFGSP VRSSDSLEVD KIRVIPNSNI LIISRTFHVS
     SKINRLAICL CLPSYYLPVV MEAWRQVSTW LDNTQASIIS IISRLKKPPS TLHLQCDKEL
     SCLLPADARF QFVSEFESII LALQRKIVPC LRSISEIPRL FLYPTTLMKF VELWFKDVFN
     WMELKDGPRM NFLSTLLAII IVNFKEELKS SESTRIAIMS GNMVVSNKLI NIISGILEPK
     YKGPLLHTDE DNELSTKLEQ LDSIDTVNTS STEIHMIKKT NSNSSISVSP ASTKYQNSNK
     GWEIPRRRSA HSVASISSGE SLAEVIQPSS LKSGSNSLHQ LYASLSNNYG TSYGSWFNKR
     PNISQFMQYS SPSNSNESWD RAASIHRTNS GNSIQQLRAG FGITPQQSPS ISEYDEYPWF
     GTPNSPHVEN SATATTSNTT VSSASVPWTT KSITEPNRMY NVHIERDFQR ISQTELLDDA
     FDKICKPGRK LECGLTVTPG NMIHAGVLEI EILNQDCVEK SSELLPRYTS YLRNYNSWFK
     LQAFPANNES ESKVITSMKK DLSVYSYSKA LLISLSTRDI KEVTIKKEYK NNTQDTNSFK
     LIQKTARMFH NGKPQANLSL ELNNCILLIE STLKRASELL KPIQSSADTS TAMTQEARQE
     ELLKLFKSII YFKDTKT