ID   LST4_YEAS7              Reviewed;         828 AA.
AC   A6ZZE9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Protein LST4;
DE   AltName: Full=Lethal with SEC30 protein 4;
GN   Name=LST4; ORFNames=SCY_3209;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Involved in extracellular amino acid uptake. Required for the
CC       trafficking of the GAP1 nitrogen-regulated general amino acid permease
CC       from the Golgi to the plasma membrane (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LST4 family. {ECO:0000305}.
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DR   EMBL; AAFW02000150; EDN60104.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZZE9; -.
DR   SMR; A6ZZE9; -.
DR   PRIDE; A6ZZE9; -.
DR   EnsemblFungi; EDN60104; EDN60104; SCY_3209.
DR   HOGENOM; CLU_010482_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR041153; Longin_2.
DR   Pfam; PF18639; Longin_2; 1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Phosphoprotein; Protein transport; Transport.
FT   CHAIN           1..828
FT                   /note="Protein LST4"
FT                   /id="PRO_0000324408"
FT   DOMAIN          114..302
FT                   /note="uDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   DOMAIN          310..712
FT                   /note="cDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   DOMAIN          718..825
FT                   /note="dDENN FNIP1/2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01180"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         401
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P34239"
SQ   SEQUENCE   828 AA;  93299 MW;  B81C2C74A6C27FAB CRC64;
     MLGNLLRNKT SSSGFEKSSE HSDFSSVVPN VPVYCKAAST GTTKTAAGAL LDTAVNVEKP
     SEMLSTTSPP ILDHISDDLK LKLFGSRDIP YSRPIDTLQN NGGLGTDKIT SINEKTYAFR
     ILIIEEAGQM ACRNNYRDIF DYTTSKISNS MEQIRPSELK EYIFGSPVRS SDLTQCDKIR
     TIPNSDLVLI TRIFYYTHQY NRIAISLCIP RILLPVVAES WSSISSWLTQ TQKMLIGFLT
     KNRIMQENTG NYSNNSVIKL SNIDIRTHYP KEIEIMVQTL QKRVIPGLRS MSEIPRLFLY
     PETFKEFVHV WFKSIFNWIE IKDGPKLGFL PLLMAMIISD YRHTIRELKT SKIVILSGNM
     VVANKLLFIL SALLEPKYKG QITIRRENIR SDSSAVSRNK SNNNFVDKPE TELSTLTSTD
     NLLSRTENNS NHNCNNSNVS SNSIGSPNFH SLRKGWQIPN RRNSNTSVSV SSSESLAEVI
     QPSSFKSGSS SLHYLSSSIS SQPGSYGSWF NKRPTISQFF QPSPSLKHNE SWERLQTTAG
     NMQRTSSSSS LQQATSRLSL TTPQQSPSIS EYDEYPWMGT PGSPNVGDVS HAPPLVKNIS
     YKFPLKNVEL KRDCQRISQD DLLDEAFERI CQPSLADLNS TYEIFPGNSS YADILTTDSD
     IDDGLMNKPL ELLPKYTMYL THFNNFFQLQ ACPAGQESES RITNSMKIDL LKADYTRSLL
     VSLRSRDIRD VALKREFTGN NNNNSNQNIY DENFVGKRKY VLKQKTRKIF SCGKIGKLST
     SLENCVNFVE NSIKSAMMLY DDNGIDSELR DSEALRIFSS LVHYCNAG