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LST82_ARATH
ID   LST82_ARATH             Reviewed;         313 AA.
AC   F4IIK6; Q9SI01;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Non-functional target of rapamycin complex subunit LST8-2 {ECO:0000305};
DE            Short=TORC subunit LST8 homolog 2 {ECO:0000305};
DE   AltName: Full=Lethal with SEC13 protein 8 homolog 2 {ECO:0000305};
GN   Name=LST8-2 {ECO:0000303|PubMed:22307851};
GN   OrderedLocusNames=At2g22040 {ECO:0000312|Araport:AT2G22040};
GN   ORFNames=T16B14.11 {ECO:0000312|EMBL:AEC07254.1},
GN   T16B14_11 {ECO:0000312|EMBL:AEC07254.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22307851; DOI=10.1105/tpc.111.091306;
RA   Moreau M., Azzopardi M., Clement G., Dobrenel T., Marchive C., Renne C.,
RA   Martin-Magniette M.-L., Taconnat L., Renou J.-P., Robaglia C., Meyer C.;
RT   "Mutations in the Arabidopsis homolog of LST8/GbetaL, a partner of the
RT   target of Rapamycin kinase, impair plant growth, flowering, and metabolic
RT   adaptation to long days.";
RL   Plant Cell 24:463-481(2012).
CC   -!- FUNCTION: Probable non-functional protein.
CC       {ECO:0000305|PubMed:22307851}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=F4IIK6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=F4IIK6-2; Sequence=VSP_059667;
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:22307851}.
CC   -!- MISCELLANEOUS: The existence of a second LST8 copy gene is specific to
CC       Arabidopsis and could be the result of a recent duplication. The
CC       expression of this duplicated gene (At2g22040) could not be detected
CC       experimentally. Could be a non-functional gene.
CC       {ECO:0000305|PubMed:22307851}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC       site. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WD repeat LST8 family. {ECO:0000305}.
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DR   EMBL; AC007019; AAM15346.1; -; Genomic_DNA.
DR   EMBL; AC007232; AAD25820.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07254.1; -; Genomic_DNA.
DR   PIR; C84608; C84608.
DR   RefSeq; NP_179795.2; NM_127773.2. [F4IIK6-1]
DR   AlphaFoldDB; F4IIK6; -.
DR   SMR; F4IIK6; -.
DR   STRING; 3702.AT2G22040.1; -.
DR   PaxDb; F4IIK6; -.
DR   PRIDE; F4IIK6; -.
DR   EnsemblPlants; AT2G22040.1; AT2G22040.1; AT2G22040. [F4IIK6-1]
DR   GeneID; 816739; -.
DR   Gramene; AT2G22040.1; AT2G22040.1; AT2G22040. [F4IIK6-1]
DR   KEGG; ath:AT2G22040; -.
DR   Araport; AT2G22040; -.
DR   TAIR; locus:2052606; AT2G22040.
DR   eggNOG; KOG0315; Eukaryota.
DR   HOGENOM; CLU_000288_57_5_1; -.
DR   InParanoid; F4IIK6; -.
DR   OMA; ECQREFR; -.
DR   OrthoDB; 779909at2759; -.
DR   PRO; PR:F4IIK6; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; F4IIK6; baseline and differential.
DR   GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR   GO; GO:0031932; C:TORC2 complex; IBA:GO_Central.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037588; MLST8.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19842; PTHR19842; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..313
FT                   /note="Non-functional target of rapamycin complex subunit
FT                   LST8-2"
FT                   /id="PRO_0000444993"
FT   REPEAT          1..35
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          38..76
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          82..121
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          123..162
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          166..205
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          215..255
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          258..297
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         229..231
FT                   /note="NNR -> NK (in isoform 2)"
FT                   /id="VSP_059667"
SQ   SEQUENCE   313 AA;  35952 MW;  BB5940DF9E705C5A CRC64;
     MFENKPDDSP VYLATASHDQ TIRLWQARTG RCYFSFRYPD LHVNRLELTP EKGKLVAACN
     PHIRLFDLRS YNPHIPVRNF VSHTKNVMAV GFQYTGHMMY SGSEDGSVKI WDLRVRECQR
     EFRSVSPVNT VVLHPNQTEL ISGDQNGNIR VWDLRADLCS CELVPEVGTP IRSLTVMWDG
     TMVVAANDRG TCYVWRSLCE RQTMTEFEPL HKLQAHNSHI LKCLLSPGNN RYLATASSDK
     TVKIWNLDGF KLEKVLTGHE RWVWDCDFSM DGEYLVTASS DTTARLWSMR AGKEEMVYQA
     HRKATVCCTL LRD
 
 
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