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LST8_ORYSJ
ID   LST8_ORYSJ              Reviewed;         316 AA.
AC   Q9AYE4; Q7Y013;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Target of rapamycin complex subunit LST8 {ECO:0000305};
DE            Short=TORC subunit LST8 {ECO:0000305};
DE   AltName: Full=Lethal with SEC13 protein 8 homolog {ECO:0000305};
DE   AltName: Full=WD40 repeat-containing protein 81 {ECO:0000303|PubMed:22429805};
DE            Short=OsWD40-81 {ECO:0000303|PubMed:22429805};
GN   Name=LST8 {ECO:0000303|PubMed:25956502};
GN   OrderedLocusNames=Os03g0681700 {ECO:0000312|EMBL:BAF12821.1},
GN   LOC_Os03g47780 {ECO:0000312|EMBL:ABF98218.1};
GN   ORFNames=OsJ_12123 {ECO:0000312|EMBL:EEE59699.1},
GN   OSJNBa0003G23.2 {ECO:0000312|EMBL:AAK00964.1},
GN   OSJNBb0070O09.2 {ECO:0000312|EMBL:AAP68374.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX   PubMed=22429805; DOI=10.1186/1471-2164-13-100;
RA   Ouyang Y., Huang X., Lu Z., Yao J.;
RT   "Genomic survey, expression profile and co-expression network analysis of
RT   OsWD40 family in rice.";
RL   BMC Genomics 13:100-100(2012).
RN   [7]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=25956502; DOI=10.1007/s00438-015-1056-0;
RA   Maegawa K., Takii R., Ushimaru T., Kozaki A.;
RT   "Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8,
RT   between rice and yeast.";
RL   Mol. Genet. Genomics 290:2019-2030(2015).
CC   -!- FUNCTION: Component of TORC1 complex, which is an essential cell growth
CC       regulator that controls plant development. Acts by activating
CC       transcription, protein synthesis and ribosome biogenesis, and
CC       inhibiting mRNA degradation and autophagy.
CC       {ECO:0000305|PubMed:25956502}.
CC   -!- SUBUNIT: The target of rapamycin complex 1 (TORC1) is composed of at
CC       least RAPTOR, LST8 and TOR. {ECO:0000305|PubMed:25956502}.
CC   -!- SIMILARITY: Belongs to the WD repeat LST8 family. {ECO:0000305}.
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DR   EMBL; AC079736; AAK00964.1; -; Genomic_DNA.
DR   EMBL; AC087412; AAP68374.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF98218.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF12821.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS85765.1; -; Genomic_DNA.
DR   EMBL; CM000140; EEE59699.1; -; Genomic_DNA.
DR   RefSeq; XP_015628391.1; XM_015772905.1.
DR   RefSeq; XP_015628392.1; XM_015772906.1.
DR   AlphaFoldDB; Q9AYE4; -.
DR   SMR; Q9AYE4; -.
DR   STRING; 4530.OS03T0681700-01; -.
DR   PaxDb; Q9AYE4; -.
DR   PRIDE; Q9AYE4; -.
DR   EnsemblPlants; Os03t0681700-01; Os03t0681700-01; Os03g0681700.
DR   GeneID; 4333729; -.
DR   Gramene; Os03t0681700-01; Os03t0681700-01; Os03g0681700.
DR   KEGG; osa:4333729; -.
DR   eggNOG; KOG0315; Eukaryota.
DR   HOGENOM; CLU_000288_57_5_1; -.
DR   InParanoid; Q9AYE4; -.
DR   OMA; VQRNYKH; -.
DR   OrthoDB; 779909at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000007752; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR   GO; GO:0031932; C:TORC2 complex; IBA:GO_Central.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037588; MLST8.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   PANTHER; PTHR19842; PTHR19842; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Growth regulation; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..316
FT                   /note="Target of rapamycin complex subunit LST8"
FT                   /id="PRO_0000444991"
FT   REPEAT          1..32
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          33..71
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          76..115
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          117..156
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          160..199
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          209..252
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          255..296
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  35324 MW;  91055E5087ED8F24 CRC64;
     MAQPSVILAT ASYDHSIKFW EAKSGRCYRT LQHTESHINR LEITPDKRFL AAAGNPHIRL
     FDINSNSNHP VISYDSHTSN VMAVGFHCDG NWMYSGSEDG TVRIWDLRTA TCQREYESRA
     AVNTVVLHPN QKELISGDQN GNIRVWDLAA NSCSCELVPE VDTAVRSLTV MWDGSMVVAA
     NNRGTCYVWR LLKGTQTITC FEPLHKLQAH DGYILKCLLS PEFCDPNRYL ATASSDHTVK
     IWNVDGFKLE KTLVGHQRWV WDCVFSVDGA YLITASSDTT ARLWTMSTGE AIRVYTSHHK
     PVVCCALHDG AESAPS
 
 
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