ID   LST8_XENLA              Reviewed;         326 AA.
AC   Q6PA72;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Target of rapamycin complex subunit lst8;
DE            Short=TORC subunit lst8;
DE   AltName: Full=G protein beta subunit-like;
DE            Short=Gable;
DE            Short=Protein GbetaL;
DE   AltName: Full=MTOR associated protein, LST8 homolog;
GN   Name=mlst8; Synonyms=gbl, lst8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat LST8 family. {ECO:0000305}.
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DR   EMBL; BC060429; AAH60429.1; -; mRNA.
DR   RefSeq; NP_001083382.1; NM_001089913.1.
DR   AlphaFoldDB; Q6PA72; -.
DR   SMR; Q6PA72; -.
DR   BioGRID; 100223; 1.
DR   IntAct; Q6PA72; 2.
DR   DNASU; 398895; -.
DR   GeneID; 398895; -.
DR   KEGG; xla:398895; -.
DR   CTD; 398895; -.
DR   OMA; VQRNYKH; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 398895; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037588; MLST8.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   PANTHER; PTHR19842; PTHR19842; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..326
FT                   /note="Target of rapamycin complex subunit lst8"
FT                   /id="PRO_0000326503"
FT   REPEAT          1..37
FT                   /note="WD 1"
FT   REPEAT          40..80
FT                   /note="WD 2"
FT   REPEAT          83..122
FT                   /note="WD 3"
FT   REPEAT          126..165
FT                   /note="WD 4"
FT   REPEAT          168..207
FT                   /note="WD 5"
FT   REPEAT          218..257
FT                   /note="WD 6"
FT   REPEAT          268..309
FT                   /note="WD 7"
SQ   SEQUENCE   326 AA;  36118 MW;  4A93AF8A8C3C6752 CRC64;
     MNSTQGTVGS DPVILATAGY DHTVRFWQAH SGICTRTVQH QDSQVNSLEV TPDRSMIAAA
     GYQHIRMYDL NSNNPNPVIN YDGVSKNITS VGFHEDGRWM YTGGEDCMAR IWDLRSRNLQ
     CQRIFQVNAP INCVFLHPNQ AELIVGDQSG AIHIWDLKTD QNEQLIPETD VSINSVHIDP
     DASYMAAVNS SGNCFVWNLT GGLGEDLTQL IPKTKIPAHK RCALKCKFSP DSTLLATCSA
     DQTCKIWRTS NFSLMTELSI KSNNPGETSR GWMWDCAFSG DSQYIVTASS DNLARLWCVE
     TGEIKREYSG HQKAVVCLAF NDSVLG