LSY27_CAEEL
ID LSY27_CAEEL Reviewed; 250 AA.
AC O45526; H9G332;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Zinc finger protein lsy-27 {ECO:0000305};
GN Name=lsy-27 {ECO:0000312|WormBase:F47H4.1a};
GN ORFNames=F47H4.1 {ECO:0000312|WormBase:F47H4.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF SER-148.
RX PubMed=21555395; DOI=10.1534/genetics.111.129064;
RA Zhang F., O'Meara M.M., Hobert O.;
RT "A left/right asymmetric neuronal differentiation program is controlled by
RT the Caenorhabditis elegans lsy-27 zinc-finger transcription factor.";
RL Genetics 188:753-759(2011).
CC -!- FUNCTION: Involved in regulating left/right asymmetric differentiation
CC of the gustatory ASE neurons (PubMed:21555395). Plays a role in
CC modulating expression of LIM/homeobox protein lim-6 (PubMed:21555395).
CC {ECO:0000269|PubMed:21555395}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:F47H4.1a};
CC IsoId=O45526-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F47H4.1b};
CC IsoId=O45526-2; Sequence=VSP_061399;
CC -!- DEVELOPMENTAL STAGE: Expressed very broadly throughout the embryo, from
CC the one-cell stage until the comma stage, when expression diminishes,
CC and is not observed after hatching in larvae or in adults
CC (PubMed:21555395). Expressed in both ASE neurons in the comma-stage
CC embryo (PubMed:21555395). {ECO:0000269|PubMed:21555395}.
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DR EMBL; BX284605; CAB07203.1; -; Genomic_DNA.
DR EMBL; BX284605; CCG28095.1; -; Genomic_DNA.
DR PIR; T22368; T22368.
DR RefSeq; NP_001256739.1; NM_001269810.1.
DR RefSeq; NP_001256740.1; NM_001269811.1.
DR AlphaFoldDB; O45526; -.
DR DIP; DIP-26919N; -.
DR IntAct; O45526; 1.
DR STRING; 6239.F47H4.1a; -.
DR EPD; O45526; -.
DR PaxDb; O45526; -.
DR EnsemblMetazoa; F47H4.1a.1; F47H4.1a.1; WBGene00009834. [O45526-1]
DR EnsemblMetazoa; F47H4.1b.1; F47H4.1b.1; WBGene00009834. [O45526-2]
DR GeneID; 180149; -.
DR KEGG; cel:CELE_F47H4.1; -.
DR UCSC; F47H4.1; c. elegans. [O45526-1]
DR CTD; 180149; -.
DR WormBase; F47H4.1a; CE16062; WBGene00009834; lsy-27.
DR WormBase; F47H4.1b; CE47185; WBGene00009834; lsy-27.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00970000195965; -.
DR HOGENOM; CLU_098769_0_0_1; -.
DR InParanoid; O45526; -.
DR OMA; NEDIHIH; -.
DR OrthoDB; 1600969at2759; -.
DR PhylomeDB; O45526; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00009834; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; O45526; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..250
FT /note="Zinc finger protein lsy-27"
FT /id="PRO_0000454831"
FT ZN_FING 25..48
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 52..75
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 81..104
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 126..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..46
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061399"
FT MUTAGEN 148
FT /note="S->L: In ot108; defects in left/right asymmetry in
FT the gustatory ASE neurons. Significantly reduced expression
FT of LIM homeobox protein lim-6."
FT /evidence="ECO:0000269|PubMed:21555395"
SQ SEQUENCE 250 AA; 27806 MW; C80CADD677421807 CRC64;
MTSIHSPVTR KEDTELKRPD LRGKFVCSSC SQNFQHSASL NRHRQLMHSN EHTCMMCERA
LNQKETIREH MRNEHNLAQV FTCGCCNWTF ASKRQLTEHT KCIQGTGAPG DTIPIAKSIN
APGSLIQSTI QGTPPVVKTG RKRPMGGSLS PSSSVSTSIS SRDASGSPPP TEEEAERKVL
FDNAVDTILQ SKFFTYQQIT EVDTWVKIIE SANTLADTLQ RIKKSQKVKA EGPAVESKMI
PEKHVKQEIE
