LT4R1_MOUSE
ID LT4R1_MOUSE Reviewed; 351 AA.
AC O88855;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Leukotriene B4 receptor 1;
DE Short=LTB4-R 1;
DE Short=LTB4-R1;
GN Name=Ltb4r; Synonyms=Bltr, Ltb4r1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9743525; DOI=10.1084/jem.188.6.1063;
RA Huang W.-W., Garcia-Zepeda E.A., Sauty A., Oettgen H.C., Rothenberg M.E.,
RA Luster A.D.;
RT "Molecular and biological characterization of the murine leukotriene B4
RT receptor expressed on eosinophils.";
RL J. Exp. Med. 188:1063-1074(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RA Jensen B.S., Mollerup J.;
RT "Expression cloning of a murine leukotriene B4 receptor.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv; TISSUE=Liver;
RX PubMed=10085095; DOI=10.1074/jbc.274.13.8597;
RA Martin V., Ronde P., Unett D., Wong A., Hoffman T.L., Edinger A.L.,
RA Doms R.W., Funk C.D.;
RT "Leukotriene binding, signaling, and analysis of HIV coreceptor function in
RT mouse and human leukotriene B4 receptor-transfected cells.";
RL J. Biol. Chem. 274:8597-8603(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for leukotriene B4, a potent chemoattractant
CC involved in inflammation and immune response.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed on activated leukocytes, including
CC eosinophils.
CC -!- PTM: Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes
CC desensitization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF044030; AAC61677.1; -; mRNA.
DR EMBL; AF110104; AAD09817.1; -; mRNA.
DR EMBL; AF077673; AAD43002.1; -; Genomic_DNA.
DR EMBL; BC064063; AAH64063.1; -; mRNA.
DR CCDS; CCDS27129.1; -.
DR RefSeq; NP_032545.1; NM_008519.2.
DR AlphaFoldDB; O88855; -.
DR SMR; O88855; -.
DR BioGRID; 201219; 1.
DR STRING; 10090.ENSMUSP00000051368; -.
DR BindingDB; O88855; -.
DR ChEMBL; CHEMBL2657; -.
DR GuidetoPHARMACOLOGY; 267; -.
DR GlyGen; O88855; 2 sites.
DR iPTMnet; O88855; -.
DR PhosphoSitePlus; O88855; -.
DR EPD; O88855; -.
DR MaxQB; O88855; -.
DR PaxDb; O88855; -.
DR PRIDE; O88855; -.
DR ProteomicsDB; 292123; -.
DR DNASU; 16995; -.
DR Ensembl; ENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
DR GeneID; 16995; -.
DR KEGG; mmu:16995; -.
DR UCSC; uc007uar.2; mouse.
DR CTD; 16995; -.
DR MGI; MGI:1309472; Ltb4r1.
DR VEuPathDB; HostDB:ENSMUSG00000046908; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244811; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; O88855; -.
DR OMA; CRLRSAM; -.
DR OrthoDB; 978296at2759; -.
DR PhylomeDB; O88855; -.
DR TreeFam; TF330976; -.
DR Reactome; R-MMU-391906; Leukotriene receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 16995; 3 hits in 73 CRISPR screens.
DR PRO; PR:O88855; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; O88855; protein.
DR Bgee; ENSMUSG00000046908; Expressed in granulocyte and 43 other tissues.
DR ExpressionAtlas; O88855; baseline and differential.
DR Genevisible; O88855; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; ISO:MGI.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001632; F:leukotriene B4 receptor activity; IDA:MGI.
DR GO; GO:0004974; F:leukotriene receptor activity; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IDA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR003983; Leukotriene_B4_typ-1_rcpt.
DR PANTHER; PTHR24230:SF51; PTHR24230:SF51; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01477; LTB1RECEPTOR.
DR PRINTS; PR01476; LTBRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..351
FT /note="Leukotriene B4 receptor 1"
FT /id="PRO_0000069709"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 311..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 351 AA; 38252 MW; B5B9AA94156BCD00 CRC64;
MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ KRTVTALLVL
NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG ISMYASVLLI TIMSLDRSLA
VARPFMSQKV RTKAFARWVL AGIWVVSFLL AIPVLVYRTV KWNNRTLICA PNYPNKEHKV
FHLLFEAITG FLLPFLAVVA SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL
VNLVEAGRTV AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS K
