LT4R1_RAT
ID LT4R1_RAT Reviewed; 351 AA.
AC Q9R0Q2;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Leukotriene B4 receptor 1;
DE Short=LTB4-R 1;
DE Short=LTB4-R1;
GN Name=Ltb4r; Synonyms=Blt;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=10471406; DOI=10.1006/bbrc.1999.1284;
RA Toda A., Yokomizo T., Masuda K., Nakao A., Izumi T., Shimizu T.;
RT "Cloning and characterization of rat leukotriene B4 receptor.";
RL Biochem. Biophys. Res. Commun. 262:806-812(1999).
CC -!- FUNCTION: Receptor for leukotriene B4, a potent chemoattractant
CC involved in inflammation and immune response.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in polymorphonuclear
CC leukocytes. {ECO:0000269|PubMed:10471406}.
CC -!- PTM: Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes
CC desensitization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB025230; BAA84578.1; -; Genomic_DNA.
DR PIR; JC7096; JC7096.
DR RefSeq; NP_067688.1; NM_021656.1.
DR RefSeq; XP_006252073.1; XM_006252011.3.
DR RefSeq; XP_006252074.1; XM_006252012.1.
DR RefSeq; XP_017455280.1; XM_017599791.1.
DR AlphaFoldDB; Q9R0Q2; -.
DR SMR; Q9R0Q2; -.
DR STRING; 10116.ENSRNOP00000027647; -.
DR BindingDB; Q9R0Q2; -.
DR ChEMBL; CHEMBL2126; -.
DR GuidetoPHARMACOLOGY; 267; -.
DR GlyGen; Q9R0Q2; 2 sites.
DR PhosphoSitePlus; Q9R0Q2; -.
DR PaxDb; Q9R0Q2; -.
DR GeneID; 59264; -.
DR KEGG; rno:59264; -.
DR UCSC; RGD:620410; rat.
DR CTD; 1241; -.
DR RGD; 620410; Ltb4r.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; Q9R0Q2; -.
DR OMA; CRLRSAM; -.
DR OrthoDB; 978296at2759; -.
DR PhylomeDB; Q9R0Q2; -.
DR TreeFam; TF330976; -.
DR Reactome; R-RNO-391906; Leukotriene receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:Q9R0Q2; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000020399; Expressed in esophagus and 9 other tissues.
DR Genevisible; Q9R0Q2; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:RGD.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001632; F:leukotriene B4 receptor activity; ISO:RGD.
DR GO; GO:0004974; F:leukotriene receptor activity; IDA:RGD.
DR GO; GO:0006954; P:inflammatory response; IEP:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR003983; Leukotriene_B4_typ-1_rcpt.
DR PANTHER; PTHR24230:SF51; PTHR24230:SF51; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01477; LTB1RECEPTOR.
DR PRINTS; PR01476; LTBRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..351
FT /note="Leukotriene B4 receptor 1"
FT /id="PRO_0000069710"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 311..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 351 AA; 37931 MW; 6B1660C021221994 CRC64;
MAANTTSTAA TSSPGGMSLS LLPIVLLSVA LVVGLPGNSF VVWSILKRMQ KRSVTALLVL
NLALADLAVL LTAPFFLHFL ARGTWSFEVT GCRLCHYVCG VSMYASVLLI TIMSLDRSLA
VARPFVSQKV RTKAFARWVL AGIWVVSFLL AIPVLVYRTV TPKNKTLICD SRYPSDGHKV
FHLLFEAITG FLLPFLAVVA SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL
VNLVEAGRTL AGWDKNSPAG QRLKLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
VVKLLEGTGS EVSSTRRGGT LVQTPKATPT CPEPGPTDSF MTSSTPPESS K
