LT4R2_HUMAN
ID LT4R2_HUMAN Reviewed; 358 AA.
AC Q9NPC1; Q5KU28; Q9NPE5;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 13-FEB-2019, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Leukotriene B4 receptor 2;
DE Short=LTB4-R 2;
DE Short=LTB4-R2;
DE AltName: Full=LTB4 receptor JULF2;
DE AltName: Full=Leukotriene B4 receptor BLT2;
DE AltName: Full=Seven transmembrane receptor BLTR2;
GN Name=LTB4R2; Synonyms=BLT2R, BLTR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10913346; DOI=10.1006/bbrc.2000.3152;
RA Tryselius Y., Nilsson N.E., Kotarsky K., Olde B., Owman C.;
RT "Cloning and characterization of cDNA encoding a novel human leukotriene B4
RT receptor.";
RL Biochem. Biophys. Res. Commun. 274:377-382(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10889186; DOI=10.1074/jbc.c000382200;
RA Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H.,
RA Furuichi K.;
RT "Molecular cloning and characterization of another leukotriene B4
RT receptor.";
RL J. Biol. Chem. 275:27000-27004(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11006272; DOI=10.1074/jbc.m004512200;
RA Wang S., Gustafson E., Pang L., Qiao X., Behan J., Maguire M., Bayne M.,
RA Laz T.;
RT "A novel hepatointestinal leukotriene B4 receptor: cloning and functional
RT characterization.";
RL J. Biol. Chem. 275:40686-40694(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=10934230; DOI=10.1084/jem.192.3.421;
RA Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.;
RT "A second leukotriene B4 receptor, BLT2: a new therapeutic target in
RT inflammation and immunological disorders.";
RL J. Exp. Med. 192:421-432(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hirose M., Urakawa I., Yamano S., Okazaki H.;
RT "Probable G-protein coupled receptor.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Volpe F., Patel K., Barnes A., Sanseau P., Cousens D., Green A.,
RA Marshall F.;
RT "Identification and characterisation of a novel LTB4 receptor.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Low-affinity receptor for leukotrienes including leukotriene
CC B4. Mediates chemotaxis of granulocytes and macrophages. The response
CC is mediated via G-proteins that activate a phosphatidylinositol-calcium
CC second messenger system. The rank order of affinities for the
CC leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF81261.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP23200.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB96134.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF277230; AAF81261.1; ALT_INIT; mRNA.
DR EMBL; AB044402; BAA99539.1; -; mRNA.
DR EMBL; AF308571; AAG40857.1; -; mRNA.
DR EMBL; AB008193; BAB00610.1; -; Genomic_DNA.
DR EMBL; AB029892; BAA99553.1; -; mRNA.
DR EMBL; AB083604; BAB89317.1; -; Genomic_DNA.
DR EMBL; AB032558; BAD83590.1; -; mRNA.
DR EMBL; AJ278605; CAB96134.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY268433; AAP23200.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL096870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW66030.1; -; Genomic_DNA.
DR CCDS; CCDS9625.2; -.
DR PIR; JC7356; JC7356.
DR RefSeq; NP_001158164.1; NM_001164692.2.
DR RefSeq; NP_062813.2; NM_019839.4.
DR AlphaFoldDB; Q9NPC1; -.
DR SMR; Q9NPC1; -.
DR BioGRID; 121143; 49.
DR IntAct; Q9NPC1; 46.
DR MINT; Q9NPC1; -.
DR STRING; 9606.ENSP00000445772; -.
DR BindingDB; Q9NPC1; -.
DR ChEMBL; CHEMBL3191; -.
DR DrugBank; DB06248; Amelubant.
DR DrugBank; DB12961; Leukotriene B4.
DR GuidetoPHARMACOLOGY; 268; -.
DR SwissLipids; SLP:000001556; -.
DR GlyGen; Q9NPC1; 1 site.
DR iPTMnet; Q9NPC1; -.
DR PhosphoSitePlus; Q9NPC1; -.
DR BioMuta; LTB4R2; -.
DR DMDM; 23821812; -.
DR EPD; Q9NPC1; -.
DR MassIVE; Q9NPC1; -.
DR PaxDb; Q9NPC1; -.
DR PeptideAtlas; Q9NPC1; -.
DR PRIDE; Q9NPC1; -.
DR Antibodypedia; 9159; 230 antibodies from 28 providers.
DR DNASU; 56413; -.
DR Ensembl; ENST00000533293.2; ENSP00000433290.1; ENSG00000213906.10.
DR Ensembl; ENST00000543919.1; ENSP00000445772.1; ENSG00000213906.10.
DR Ensembl; ENST00000643080.1; ENSP00000494694.1; ENSG00000285203.2.
DR Ensembl; ENST00000644309.2; ENSP00000494877.1; ENSG00000285203.2.
DR GeneID; 56413; -.
DR KEGG; hsa:56413; -.
DR MANE-Select; ENST00000533293.2; ENSP00000433290.1; NM_019839.5; NP_062813.2.
DR UCSC; uc001wor.4; human.
DR CTD; 56413; -.
DR DisGeNET; 56413; -.
DR GeneCards; LTB4R2; -.
DR HGNC; HGNC:19260; LTB4R2.
DR HPA; ENSG00000213906; Tissue enhanced (esophagus, skin).
DR MIM; 605773; gene.
DR neXtProt; NX_Q9NPC1; -.
DR OpenTargets; ENSG00000213906; -.
DR PharmGKB; PA134910672; -.
DR VEuPathDB; HostDB:ENSG00000213906; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182966; -.
DR InParanoid; Q9NPC1; -.
DR OMA; FIAQFFE; -.
DR PhylomeDB; Q9NPC1; -.
DR TreeFam; TF330976; -.
DR PathwayCommons; Q9NPC1; -.
DR Reactome; R-HSA-391906; Leukotriene receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; Q9NPC1; -.
DR SIGNOR; Q9NPC1; -.
DR BioGRID-ORCS; 56413; 119 hits in 1074 CRISPR screens.
DR GenomeRNAi; 56413; -.
DR Pharos; Q9NPC1; Tchem.
DR PRO; PR:Q9NPC1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NPC1; protein.
DR Bgee; ENSG00000213906; Expressed in skin of abdomen and 94 other tissues.
DR ExpressionAtlas; Q9NPC1; baseline and differential.
DR Genevisible; Q9NPC1; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001632; F:leukotriene B4 receptor activity; IBA:GO_Central.
DR GO; GO:0004974; F:leukotriene receptor activity; TAS:ProtInc.
DR GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0051546; P:keratinocyte migration; IEA:Ensembl.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR003982; Leukotriene_B4_typ-2_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01478; LTB2RECEPTOR.
DR PRINTS; PR01476; LTBRECEPTOR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="Leukotriene B4 receptor 2"
FT /id="PRO_0000069711"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 311..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 358 AA; 37942 MW; 5F5D98179CE00F3D CRC64;
MSVCYRPPGN ETLLSWKTSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP ARGRPLAATL
VLHLALADGA VLLLTPLFVA FLTRQAWPLG QAGCKAVYYV CALSMYASVL LTGLLSLQRC
LAVTRPFLAP RLRSPALARR LLLAVWLAAL LLAVPAAVYR HLWRDRVCQL CHPSPVHAAA
HLSLETLTAF VLPFGLMLGC YSVTLARLRG ARWGSGRHGA RVGRLVSAIV LAFGLLWAPY
HAVNLLQAVA ALAPPEGALA KLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
PRFLTRLFEG SGEARGGGRS REGTMELRTT PQLKVVGQGR GNGDPGGGME KDGPEWDL
