LT4R2_MOUSE
ID LT4R2_MOUSE Reviewed; 360 AA.
AC Q9JJL9; Q3KP98;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Leukotriene B4 receptor 2;
DE Short=LTB4-R 2;
DE Short=LTB4-R2;
DE AltName: Full=Leukotriene B4 receptor BLT2;
GN Name=Ltb4r2; Synonyms=Blt2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10934230; DOI=10.1084/jem.192.3.421;
RA Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T.;
RT "A second leukotriene B4 receptor, BLT2: a new therapeutic target in
RT inflammation and immunological disorders.";
RL J. Exp. Med. 192:421-432(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Low-affinity receptor for leukotrienes including leukotriene
CC B4. Mediates chemotaxis of granulocytes and macrophages. The response
CC is mediated via G-proteins that activate a phosphatidylinositol-calcium
CC second messenger system (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB029893; BAA99554.1; -; mRNA.
DR EMBL; BC106834; AAI06835.1; -; mRNA.
DR EMBL; BC106835; AAI06836.1; -; mRNA.
DR CCDS; CCDS27128.1; -.
DR RefSeq; NP_065236.1; NM_020490.2.
DR RefSeq; XP_006519389.1; XM_006519326.3.
DR AlphaFoldDB; Q9JJL9; -.
DR SMR; Q9JJL9; -.
DR STRING; 10090.ENSMUSP00000048358; -.
DR GuidetoPHARMACOLOGY; 268; -.
DR GlyGen; Q9JJL9; 1 site.
DR PhosphoSitePlus; Q9JJL9; -.
DR MaxQB; Q9JJL9; -.
DR PaxDb; Q9JJL9; -.
DR PRIDE; Q9JJL9; -.
DR ProteomicsDB; 293410; -.
DR Antibodypedia; 9159; 230 antibodies from 28 providers.
DR DNASU; 57260; -.
DR Ensembl; ENSMUST00000044554; ENSMUSP00000048358; ENSMUSG00000040432.
DR GeneID; 57260; -.
DR KEGG; mmu:57260; -.
DR UCSC; uc007uaq.1; mouse.
DR CTD; 56413; -.
DR MGI; MGI:1888501; Ltb4r2.
DR VEuPathDB; HostDB:ENSMUSG00000040432; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182966; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; Q9JJL9; -.
DR OMA; FIAQFFE; -.
DR OrthoDB; 978296at2759; -.
DR PhylomeDB; Q9JJL9; -.
DR TreeFam; TF330976; -.
DR Reactome; R-MMU-391906; Leukotriene receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 57260; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9JJL9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9JJL9; protein.
DR Bgee; ENSMUSG00000040432; Expressed in lip and 22 other tissues.
DR Genevisible; Q9JJL9; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001632; F:leukotriene B4 receptor activity; IDA:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0051546; P:keratinocyte migration; IDA:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IDA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR003982; Leukotriene_B4_typ-2_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01478; LTB2RECEPTOR.
DR PRINTS; PR01476; LTBRECEPTOR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..360
FT /note="Leukotriene B4 receptor 2"
FT /id="PRO_0000069712"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 311..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 360 AA; 37867 MW; 4DB5A6CB024943CF CRC64;
MSVCYRPPGN ETLLSWKGSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP TAGRPLAATL
VLHLALADGA VLLLTPLFVA FLSQEAWPLG QVGCKAVYYV CALSMYASVL LTGLLSLQRC
LAVTRPFLAP RLRSPALARR LLLGVWLAAL VLAVPAAVYR HLWGGRVCQL CHPSPVHAAA
HLSLETLTAF VLPFGTVLGC YGVTLARLRG ARWGSGRQGT RVGRLVSAIV LAFGLLWAPY
HAVNLLQAVA ALAPPEGPLA RLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
PRFLTRLFEG SGEARGGSRS REGTMELRTT PKLKVMGQGR GNGDPGGGDG GKTEKDSQEW
