LT4R2_RAT
ID LT4R2_RAT Reviewed; 358 AA.
AC Q924U0;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Leukotriene B4 receptor 2;
DE Short=LTB4-R 2;
DE Short=LTB4-R2;
DE AltName: Full=LTB4 receptor JULF2;
GN Name=Ltb4r2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10889186; DOI=10.1074/jbc.c000382200;
RA Kamohara M., Takasaki J., Matsumoto M., Saito T., Ohishi T., Ishii H.,
RA Furuichi K.;
RT "Molecular cloning and characterization of another leukotriene B4
RT receptor.";
RL J. Biol. Chem. 275:27000-27004(2000).
CC -!- FUNCTION: Low-affinity receptor for leukotrienes including leukotriene
CC B4. Mediates chemotaxis of granulocytes and macrophages. The response
CC is mediated via G-proteins that activate a phosphatidylinositol-calcium
CC second messenger system (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB052660; BAB60815.1; -; mRNA.
DR RefSeq; NP_446092.1; NM_053640.1.
DR RefSeq; XP_008768880.1; XM_008770658.2.
DR AlphaFoldDB; Q924U0; -.
DR SMR; Q924U0; -.
DR STRING; 10116.ENSRNOP00000027619; -.
DR GlyGen; Q924U0; 1 site.
DR PhosphoSitePlus; Q924U0; -.
DR PaxDb; Q924U0; -.
DR Ensembl; ENSRNOT00000027619; ENSRNOP00000027619; ENSRNOG00000020382.
DR GeneID; 114098; -.
DR KEGG; rno:114098; -.
DR UCSC; RGD:621029; rat.
DR CTD; 56413; -.
DR RGD; 621029; Ltb4r2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182966; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; Q924U0; -.
DR OMA; FIAQFFE; -.
DR OrthoDB; 978296at2759; -.
DR PhylomeDB; Q924U0; -.
DR TreeFam; TF330976; -.
DR Reactome; R-RNO-391906; Leukotriene receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:Q924U0; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000020382; Expressed in esophagus and 1 other tissue.
DR Genevisible; Q924U0; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001632; F:leukotriene B4 receptor activity; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0051546; P:keratinocyte migration; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR003982; Leukotriene_B4_typ-2_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01478; LTB2RECEPTOR.
DR PRINTS; PR01476; LTBRECEPTOR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="Leukotriene B4 receptor 2"
FT /id="PRO_0000069713"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 315..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 358 AA; 37899 MW; 4CD35D009D39319A CRC64;
MSVCYRPPGN ETLLSWKGSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP TAGRPLAATL
VLHLALADGA VLLLTPLFVA FLSRQAWPLG QVGCKAVYYV CALSMYASVL LTGLLSLQRC
LAVTRPFLAP RLRSPALARR LLLGVWLAAL VLAVPAAVYR HLWGDRVCQL CHPSAVHAAA
HLSLETLTAF VLPFGTVLGC YGVTLARLRG ARWGSGRQGT RVGRLVSAIV LAFGLLWAPY
HAVNLLQAVA ALAPPEGPLA RLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
PRFLTRLFEG SGEARVGSRS REGTMELRTT PRLKVVGQGR GYGDPGGGGR MEKDSQEW
