ID   LTAA_STAAB              Reviewed;         396 AA.
AC   Q2YWW7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Proton-coupled antiporter flippase LtaA {ECO:0000250|UniProtKB:Q2FZP8};
DE   AltName: Full=Lipoteichoic acid protein A {ECO:0000250|UniProtKB:Q2FZP8};
GN   Name=ltaA; OrderedLocusNames=SAB0882c;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: Proton-coupled antiporter flippase that catalyzes the
CC       translocation, from the inner to the outer leaflet of the cell
CC       membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors
CC       lipoteichoic acids (LTA) to the cell membrane.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2FZP8};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. LtaA family.
CC       {ECO:0000305}.
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DR   EMBL; AJ938182; CAI80570.1; -; Genomic_DNA.
DR   RefSeq; WP_001154230.1; NC_007622.1.
DR   AlphaFoldDB; Q2YWW7; -.
DR   SMR; Q2YWW7; -.
DR   KEGG; sab:SAB0882c; -.
DR   HOGENOM; CLU_054518_0_0_9; -.
DR   OMA; GYVYFAW; -.
DR   UniPathway; UPA00556; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Lipid transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..396
FT                   /note="Proton-coupled antiporter flippase LtaA"
FT                   /id="PRO_0000287152"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   396 AA;  44647 MW;  EB511094205B5445 CRC64;
     MQDSSLNNYA NHKNFILMLI ILFLMEFARG MYILSYINFL PTVTSIAVAI TSLAFSIHFI
     ADASTNFVIG FLLKKFNTKI VLTTGFILAF TSLFLVIWFP ASPFIIIFSA MMLGIAVSPI
     WVIMLSSVEE DKRGKQMGYV YFSWLLGLLV GMVFMNLLIK VHPTRFAFMM SLVVLIAWIL
     YYFVDVKLTN YNTRPVKAQL RQIVDVTKRH LLLFPGILLQ GAAIAALVPI LPTYATKVIN
     VSTIEYTVAI IIGGIGCAVS MLFLSKLIDN RSRNFMYGVI LSGFILYMIL IFTLSMIVNI
     HIVWIIALAI GLMYGILLPA WNTFMARFIK SDEQEETWGV FNSIQGFGSM IGPLFGGLIT
     QFTNNLNNTF YFSALIFLVL AVFYGSYFIA NREKAK