ID   LTAA_STAES              Reviewed;         397 AA.
AC   Q8CPR4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Proton-coupled antiporter flippase LtaA {ECO:0000250|UniProtKB:Q2FZP8};
DE   AltName: Full=Lipoteichoic acid protein A {ECO:0000250|UniProtKB:Q2FZP8};
GN   Name=ltaA; OrderedLocusNames=SE_0716;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Proton-coupled antiporter flippase that catalyzes the
CC       translocation, from the inner to the outer leaflet of the cell
CC       membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors
CC       lipoteichoic acids (LTA) to the cell membrane.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2FZP8};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. LtaA family.
CC       {ECO:0000305}.
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DR   EMBL; AE015929; AAO04313.1; -; Genomic_DNA.
DR   RefSeq; NP_764271.1; NC_004461.1.
DR   RefSeq; WP_002494345.1; NZ_WBME01000019.1.
DR   AlphaFoldDB; Q8CPR4; -.
DR   SMR; Q8CPR4; -.
DR   STRING; 176280.SE_0716; -.
DR   EnsemblBacteria; AAO04313; AAO04313; SE_0716.
DR   GeneID; 50019142; -.
DR   KEGG; sep:SE_0716; -.
DR   PATRIC; fig|176280.10.peg.690; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_054518_0_0_9; -.
DR   OMA; GYVYFAW; -.
DR   UniPathway; UPA00556; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Lipid transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..397
FT                   /note="Proton-coupled antiporter flippase LtaA"
FT                   /id="PRO_0000287161"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   397 AA;  44424 MW;  C7C1E54EBEE7C142 CRC64;
     MQDSSSSNYS SNRNFVMMLV ILFLMEFARG MYILSYINFL PTVTSIAIAI TSFAFSIHFI
     ADAATNFVIG FLLKKFGSKL VLTSGFLLAF ISLFLVIWFP ASPFIIIFSA IMLGIAVSPI
     WVIMLSSVDE RNRGKQMGYV YFSWLLGLLV GMVIMNLLIK FHPTRFAFLM ALVVLIAWVL
     YYFVNINLTN YNTKPVKAQL KQIVDVTQRH LILFPGILLQ GAAIAALVPI LPKYATQVVK
     VSTVEYTVAI IIGGIGCAFS MLFLSKIIDN NSKGFMYGVI FSGFILYTIL IFGLSTITNI
     YIVWAIGLFI GLMYGILLPA WNTFMAGHIN PNEQEETWGV FNSVQGFGSM IGPLVGGLIT
     QFTNNLNNTF YFSAMIFLAL AVFYGYYFIK TNRRVKP