ID   LTAA_STAHJ              Reviewed;         398 AA.
AC   Q4L523;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Proton-coupled antiporter flippase LtaA {ECO:0000250|UniProtKB:Q2FZP8};
DE   AltName: Full=Lipoteichoic acid protein A {ECO:0000250|UniProtKB:Q2FZP8};
GN   Name=ltaA; OrderedLocusNames=SH1943;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Proton-coupled antiporter flippase that catalyzes the
CC       translocation, from the inner to the outer leaflet of the cell
CC       membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors
CC       lipoteichoic acids (LTA) to the cell membrane.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2FZP8};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. LtaA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE05252.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP006716; BAE05252.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_029376686.1; NC_007168.1.
DR   AlphaFoldDB; Q4L523; -.
DR   SMR; Q4L523; -.
DR   STRING; 279808.SH1943; -.
DR   EnsemblBacteria; BAE05252; BAE05252; SH1943.
DR   GeneID; 58061944; -.
DR   KEGG; sha:SH1943; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_054518_0_0_9; -.
DR   UniPathway; UPA00556; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Lipid transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..398
FT                   /note="Proton-coupled antiporter flippase LtaA"
FT                   /id="PRO_0000287163"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   398 AA;  43981 MW;  EBD012416235186B CRC64;
     MPDSSLSNKG ISKNFKIMLV ILFLMEFARG MYVLSYVNYL PTVTSIAVAV TSAALSIHFI
     SDAATNFVIG FLLKKFGTKL VLTLGFLLAF ISLFLVIWFP TNPIVIILSA IMLGIAVSPI
     WVIMLSSVEE AQRGKQMGYV YFAWLLGLLV GWAFMNVLVK LHPTRFAFMM SLVVVIAWVL
     YYFVDIKLTN YNTKPVSEQL GQIVDVMKRH LVLFPGILLQ GASISALLPI LPTYATKVVG
     VSTIEYTIAI AIGGAGCAFS MLFLSKIIDK NSKGFMYAVI FTGFILFTAF IFGLSLVTNI
     LIVWIVAIFI GLMYGILLPA WNTFMAGQID PAEQEETWGV FNSVQGFGSM IGPLFGGLIA
     QFSNGLNNTF YFSAAIFLVL AIFYGVYFVK YRGKANRF