ID   LTAA_STAS1              Reviewed;         398 AA.
AC   Q49WE5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Proton-coupled antiporter flippase LtaA {ECO:0000250|UniProtKB:Q2FZP8};
DE   AltName: Full=Lipoteichoic acid protein A {ECO:0000250|UniProtKB:Q2FZP8};
GN   Name=ltaA; OrderedLocusNames=SSP1769;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Proton-coupled antiporter flippase that catalyzes the
CC       translocation, from the inner to the outer leaflet of the cell
CC       membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors
CC       lipoteichoic acids (LTA) to the cell membrane.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2FZP8};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q2FZP8}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. LtaA family.
CC       {ECO:0000305}.
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DR   EMBL; AP008934; BAE18914.1; -; Genomic_DNA.
DR   RefSeq; WP_011303474.1; NZ_CP035294.1.
DR   AlphaFoldDB; Q49WE5; -.
DR   SMR; Q49WE5; -.
DR   STRING; 342451.SSP1769; -.
DR   EnsemblBacteria; BAE18914; BAE18914; SSP1769.
DR   KEGG; ssp:SSP1769; -.
DR   PATRIC; fig|342451.11.peg.1765; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_054518_0_0_9; -.
DR   OMA; GYVYFAW; -.
DR   UniPathway; UPA00556; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Lipid transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..398
FT                   /note="Proton-coupled antiporter flippase LtaA"
FT                   /id="PRO_0000287164"
FT   TRANSMEM        15..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   398 AA;  44327 MW;  C3DA7407FF29BA52 CRC64;
     MQSSSLNNYN SNKNFIIMLI ILFLMEFARG MYILSYLALL PTATSIAVGI TSIAISIHFI
     ADATTNFVIG FLLKRLGTKL VLTLGFLLAF ASLFLVIWFP TSPFVLIASA ILLGIAVSPI
     WVIMLASVDE NNRGKQMGYV YFSWLLGLLV GMVGMNVIFK FHPTQFAFLM SLVVLIAWIL
     YYFVKVRLTN YNTRPVKQQL GQIVDVTKRH MILFPGILLQ GASITALVPI LPTYATKVVG
     VSTLEYTMAI VFGGIGCAIS MLFLSKIIDK HGTLFMYWVI FGGFVLYTLM IFALSLITNI
     TIVWVLAVFI GLMYGILLPA WNTFMASHIH SDEQEETWGV FNSVQGFGSM IGPLVGGLIT
     EFTKSVNNTF YFSALVFLFL AIFYGIYFVK VNNKTKTS