LTD_ARATH
ID LTD_ARATH Reviewed; 175 AA.
AC Q8VY88; Q9C6J0;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Protein LHCP TRANSLOCATION DEFECT;
DE AltName: Full=Protein GRANA-DEFICIENT CHLOROPLAST 1;
DE Flags: Precursor;
GN Name=LTD; Synonyms=GDC1; OrderedLocusNames=At1g50900; ORFNames=F8A12.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION PHENOTYPE,
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION BY LIGHT.
RX PubMed=21098677; DOI=10.1104/pp.110.165589;
RA Cui Y.L., Jia Q.S., Yin Q.Q., Lin G.N., Kong M.M., Yang Z.N.;
RT "The GDC1 gene encodes a novel ankyrin domain-containing protein that is
RT essential for grana formation in Arabidopsis.";
RL Plant Physiol. 155:130-141(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP CAO/CPSRP43; LHCP; TIC40 AND TIC110.
RX PubMed=21505433; DOI=10.1038/ncomms1278;
RA Ouyang M., Li X., Ma J., Chi W., Xiao J., Zou M., Chen F., Lu C., Zhang L.;
RT "LTD is a protein required for sorting light-harvesting chlorophyll-binding
RT proteins to the chloroplast SRP pathway.";
RL Nat. Commun. 2:277-277(2011).
CC -!- FUNCTION: Involved in the import of light-harvesting complex proteins
CC (LHCP) and subsequent routing of these proteins to the chloroplast
CC signal recognition particle (SRP) pathway.
CC {ECO:0000269|PubMed:21098677, ECO:0000269|PubMed:21505433}.
CC -!- SUBUNIT: Interacts with CAO/cpSRP43, but is not a component of the
CC transit complex. Interacts with LHCP (via T14 domain), TIC40 and
CC TIC110. {ECO:0000269|PubMed:21505433}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane;
CC Peripheral membrane protein. Plastid, chloroplast envelope. Plastid,
CC chloroplast stroma.
CC -!- TISSUE SPECIFICITY: Highly expressed in leaves and seedlings. Detected
CC in roots, but not in germinating seeds. {ECO:0000269|PubMed:21098677}.
CC -!- INDUCTION: Up-regulated by light. {ECO:0000269|PubMed:21098677}.
CC -!- DISRUPTION PHENOTYPE: Not able to grow photoautotrophically in soil.
CC Pale green, slow growth and no bolting. No appressed grana in
CC chloroplasts. {ECO:0000269|PubMed:21098677,
CC ECO:0000269|PubMed:21505433}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50930.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC079284; AAG50930.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32599.1; -; Genomic_DNA.
DR EMBL; AY072348; AAL61955.1; -; mRNA.
DR EMBL; AY114573; AAM47892.1; -; mRNA.
DR EMBL; AY085852; AAM63065.1; -; mRNA.
DR PIR; A96546; A96546.
DR RefSeq; NP_564580.1; NM_103970.3.
DR AlphaFoldDB; Q8VY88; -.
DR SMR; Q8VY88; -.
DR BioGRID; 26737; 2.
DR IntAct; Q8VY88; 2.
DR STRING; 3702.AT1G50900.1; -.
DR TCDB; 3.A.9.1.2; the chloroplast envelope protein translocase (cept or tic-toc) family.
DR iPTMnet; Q8VY88; -.
DR PaxDb; Q8VY88; -.
DR PRIDE; Q8VY88; -.
DR ProteomicsDB; 238504; -.
DR EnsemblPlants; AT1G50900.1; AT1G50900.1; AT1G50900.
DR GeneID; 841512; -.
DR Gramene; AT1G50900.1; AT1G50900.1; AT1G50900.
DR KEGG; ath:AT1G50900; -.
DR Araport; AT1G50900; -.
DR TAIR; locus:2036421; AT1G50900.
DR eggNOG; ENOG502RYRG; Eukaryota.
DR HOGENOM; CLU_132294_0_0_1; -.
DR InParanoid; Q8VY88; -.
DR OMA; CFFKFGN; -.
DR OrthoDB; 1468489at2759; -.
DR PRO; PR:Q8VY88; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8VY88; baseline and differential.
DR Genevisible; Q8VY88; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; IDA:UniProtKB.
DR GO; GO:0009570; C:chloroplast stroma; IDA:UniProtKB.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090391; P:granum assembly; IMP:TAIR.
DR GO; GO:0006886; P:intracellular protein transport; IDA:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR044242; LTD-like.
DR PANTHER; PTHR47317; PTHR47317; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Chloroplast; Membrane; Plastid; Protein transport;
KW Reference proteome; Thylakoid; Transit peptide; Transport.
FT TRANSIT 1..68
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 69..175
FT /note="Protein LHCP TRANSLOCATION DEFECT"
FT /id="PRO_0000413432"
FT REPEAT 117..149
FT /note="ANK"
SQ SEQUENCE 175 AA; 19190 MW; 7F72AB1EC82C4190 CRC64;
MASSSISFSC APSLATSLFS TTSSSPRLLS SRFLGTRNLK LRIRPARLGP SNGSRTTCWF
KFGKNGVDAE NAGIYGSQSR DDFDRDDVEQ YFNYMGMLAV EGTYSKMEAL LNLNIHPVDI
LLMLAATEGD RPKIEELLKA GADYSVKDAD GRTAIDRANS EEIRDLILGY STQKA
