LTE1_ASHGO
ID LTE1_ASHGO Reviewed; 1439 AA.
AC Q75BH9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Guanine nucleotide exchange factor LTE1;
GN Name=LTE1; OrderedLocusNames=ACR292W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: GDP-GTP exchange factor component of the mitotic exit network
CC (MEN). Fine-tunes the timing of the mitotic exit and couples this event
CC with cytokinesis. May also be involved in proprotein-processing in the
CC secretory pathway (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Bud {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LTE1 family. {ECO:0000305}.
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DR EMBL; AE016816; AAS51518.1; -; Genomic_DNA.
DR RefSeq; NP_983694.1; NM_209047.1.
DR AlphaFoldDB; Q75BH9; -.
DR SMR; Q75BH9; -.
DR STRING; 33169.AAS51518; -.
DR EnsemblFungi; AAS51518; AAS51518; AGOS_ACR292W.
DR GeneID; 4619829; -.
DR KEGG; ago:AGOS_ACR292W; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_004883_0_0_1; -.
DR InParanoid; Q75BH9; -.
DR OMA; PFILMYD; -.
DR Proteomes; UP000000591; Chromosome III.
DR GO; GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0061510; P:asymmetric protein localization to new mitotic spindle pole body; IEA:EnsemblFungi.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0031536; P:positive regulation of exit from mitosis; IEA:EnsemblFungi.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:EnsemblFungi.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Guanine-nucleotide releasing factor;
KW Mitosis; Reference proteome.
FT CHAIN 1..1439
FT /note="Guanine nucleotide exchange factor LTE1"
FT /id="PRO_0000285404"
FT DOMAIN 37..167
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT DOMAIN 1197..1438
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 525..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1439 AA; 160951 MW; 35CB38DCC07F138D CRC64;
MRAEGNDMAE SGRAVFSAAD YYPAPSGRVI TYAAGGRGRQ IMAADVTALV AALTSPVDGV
EYELFADFFL VYRNFLEARR LLELLEARFD WSLGEIGAGR AKARVVGEIT LVRTFVLLRH
WVINYFAQDF LPDVALRERF LAFVNGLGGA AGGTRPKIVA NIVVSLKKTW AYTVRLIWDD
LDLEREFELR SADAWLQFQI PDVTQLKTEA GLQRDSRLSF YARQSSTNPS FRNESVLSLY
RPKDNFQLPV RNNDYNIKQG TRIKKRTASM FLYPQDSLNA PSGNQKPQCS LEPPFPAHSH
VRKISHISKV TNVSNVIKEV AYPTSPAVES FFPPTPSKKL EFTVNSTYVP PAAAECSREP
SAQKKPRSPN GYRAVTGLLS KWRMNHLSRH KACDRTSTVE PAMDNLIKYV FSISSLESPK
GDIQEEREIS PSKFDILSAR TIEEVEHLIT VENEVLQKVT AHEGKVPITS SSAREARFPP
LLNEAPLLDQ APLGNGQEYS VIDNLNLYRT VSTIATSVIK LTRTASQRQT KVTLPPPPPL
RQRPTSLSAF RGSSSRMLLS DSLRRDGYQN SKASLHLRPL ASADENAEGS SVQASNPPQV
IFHTHALIKT PTDKVFDAKA VEDTSPKTSL VSTQVTDARP PSYESTITYD SDLQDITMRD
YNTSNQTENH NDGTLDTNQP ILNRKTNHSN LREFLFEAST SGSPAAHTTQ EPTDESTGRL
GACPTVMRSI SEPIPTVMRS NNGDTHTKAK PEFNIQSHDD TFSRKPMRPS LLSPPINIRG
SFDTLHRKNV PAPISVPPNP VTKNASVSPA SGRISIIKKS GNRTSPTTRS PLLDTTSAFM
EKTDSFAKQE ASLNALENDL QAILITTGRR SSTFSKSGTD STIATNVLLE SIQTSPQKNT
HLMTNISEDD SASNTDTKPM EFSSVGIESS ASNSSSFADA LCEPANRSSP SHNPYSGQCT
TIEDRYRRSR FASQPDSLLG YINENGNKYI FSPGETAEDA SPKKDMETLK TKFMTTKEPP
VCPSGNDADL ALIISKLKET NPSAERIETE NPNDDANNLT PPATSSSNNE NSSDPVAVAL
MKLEGTFAKP AKEDNTASKL NSPRSSVLAK EVEKLDFQKW RFPSSKTMNK RQSMFIERRR
TMTDIFSSAT EDTSSEEQSP KLSDREIREL LETYKLQDPR LNIKNVEHHV PFILMYDSCS
IAKQMTLIER EVMNEIDWKD LLDLNMKKSL PRVTSWLQLL LHNEELSGID LAIARFNLTV
DWIISELVMT TDIKLRRNAI QRLIHVAEHC RMYQNYNTVM EIVLALNSVV VQKFTSSWRL
IEPADMLTWE HLKSIPSLDR NYHNVRNLLN SIDPIKGCIP FLVVYLSDLA LNSEKRDWIV
PNEIVNYNKF QTNVQIVKNF IQRVQWARFY DIRADEDLLS KCVYISALSH EEIGYLTSF
