ID   LTE1_CANGA              Reviewed;        1318 AA.
AC   Q6FT12;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Guanine nucleotide exchange factor LTE1;
GN   Name=LTE1; OrderedLocusNames=CAGL0G06226g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: GDP-GTP exchange factor component of the mitotic exit network
CC       (MEN). Fine-tunes the timing of the mitotic exit and couples this event
CC       with cytokinesis. May also be involved in proprotein-processing in the
CC       secretory pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Bud {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LTE1 family. {ECO:0000305}.
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DR   EMBL; CR380953; CAG59559.1; -; Genomic_DNA.
DR   RefSeq; XP_446632.1; XM_446632.1.
DR   AlphaFoldDB; Q6FT12; -.
DR   SMR; Q6FT12; -.
DR   STRING; 5478.XP_446632.1; -.
DR   EnsemblFungi; CAG59559; CAG59559; CAGL0G06226g.
DR   GeneID; 2888077; -.
DR   KEGG; cgr:CAGL0G06226g; -.
DR   CGD; CAL0129973; CAGL0G06226g.
DR   VEuPathDB; FungiDB:CAGL0G06226g; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_004883_0_0_1; -.
DR   InParanoid; Q6FT12; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0061510; P:asymmetric protein localization to new mitotic spindle pole body; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0031536; P:positive regulation of exit from mitosis; IEA:EnsemblFungi.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:EnsemblFungi.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Guanine-nucleotide releasing factor;
KW   Mitosis; Reference proteome.
FT   CHAIN           1..1318
FT                   /note="Guanine nucleotide exchange factor LTE1"
FT                   /id="PRO_0000285405"
FT   DOMAIN          29..164
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          1073..1314
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   REGION          694..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1318 AA;  150362 MW;  A919771CEC287D67 CRC64;
     MDIFSQRDYY PIPSDDVIKY KHMVHKKWNK NEVIQADIPS IIVHLSSPVD SVDYKGFSDF
     FLFYRNFLTP AELYDYLILR FKWCMREIES YQHQRSGDNQ LRIGKVALIR TFVLLRHGIL
     NHFADDFLLN ENLRLRLISF FNEDIKSDMK VIVSCLISLK KAWLHAMKLN WDNVLFNEPA
     FSAYTDWIDY KIKDVSQLDM AQKRNSRFSY HGIQSISNPD MRNRSILSIY KSDNFDHMVQ
     SNSNKISRNR TPSTLLFQKD SSNSEMATVY SNRKGAQKKT IALPNILTSE LDRKDVMSNV
     TRMSHIIQDA KTLRSSDVNK IIPSTPAKKV ELILNTIYSP DCLESENIQE SLNQDTSSTQ
     KSFPKGIMSL LARWKKNHKI ADPKIRKPVG FTNKREAELD NFVKYVISIS SLTNKEEDLK
     RLNENLDSKF DILSARTIDE VEYLFRLESK LLAQLSTMQK TTRTLSNDEF NDVNVPNNID
     SKQISAMDNL DLFRTVNGVA RSVISLTNSV NKLNNLSDHS VLDRRRVKSS MPNFYNRERS
     LSGLSNYAGL QFYDASSEMS AEDDKPQKLV FHDGVDELKN HLTQTFTKPG SISNSSPLKK
     VLPNLFEHPS VDSLASGDAC SYVTYDSQLS QMGTVKKSMK DETSRYSNYE GPVLKKKVAY
     DNLREFTFED SKEIIKNDTS SLIDILNSPV TPDLSILPQT PTGKGSVQHK KKEKSESIIS
     PASGRISIAK SHHMSLSPNL TKLKEDDEYV KGDNSLGQAE DELIRLEKNL RDSKLENYNT
     VVAGNLGAGS GSSTPLGDSP TNVFELPSSI NMVESDMDTE SFESSFEQRQ PTNLREQYFK
     SIGSPETASP RKVNSNNAYS QVSSQMSPSL ANKYLFSPDN ESLDIASPVK NVEDLKSRFL
     KGNNQSASSS QIGASINTSV TATPKNNDMF GSDFDKNGLK NIMTASEEKL SKDPVELAMM
     KLEGTFKKNK SGNNTGYSSD LEKEVDILNI ANLPEMNANP SDKRKSLMLD RRRQTMFNIG
     PSIYPSNTND EGYDEESITD DKIWSLIAQY HIDDENLLAK NHANHVPFIL MYESKDVAQQ
     FTLIEREILS EIDWKDLLDI KLLYKGPNLT SWLQLLIQNQ EFTGIDLAVA RFNLTVDWAI
     SEIVLTTDLK MRRNTIERFI HVAEHCRKLQ NFNTMMQIIL ALNSVVVQKF TEAWRLIEPG
     DMLLWEDLRK IPALDWNYHA LRTMMKTVDP LKGCIPFIVV YLSDLTINSE KNTWIVEKRV
     VNYSKFSTCV QIVKNFIQKV QWSSFYDIIP IQELLSKCIY ISSLSQDEIE HLTAEFAR