LTG11_ARATH
ID LTG11_ARATH Reviewed; 169 AA.
AC Q9ZQI8; Q3EC14; Q84WL8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Non-specific lipid transfer protein GPI-anchored 11 {ECO:0000303|PubMed:23893219};
DE Short=AtLTPG-11 {ECO:0000303|PubMed:23893219};
DE Short=Protein LTP-GPI-ANCHORED 11 {ECO:0000303|PubMed:23893219};
DE AltName: Full=Xylogen protein 2 {ECO:0000303|PubMed:15215864, ECO:0000303|PubMed:21558309};
DE Short=AtXYP2 {ECO:0000303|PubMed:15215864, ECO:0000303|PubMed:21558309};
DE Flags: Precursor;
GN Name=LTPG11 {ECO:0000303|PubMed:23893219};
GN Synonyms=XYP2 {ECO:0000303|PubMed:15215864, ECO:0000303|PubMed:21558309};
GN OrderedLocusNames=At2g13820 {ECO:0000312|Araport:AT2G13820};
GN ORFNames=F17L24.13 {ECO:0000312|EMBL:AAD15432.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15215864; DOI=10.1038/nature02613;
RA Motose H., Sugiyama M., Fukuda H.;
RT "A proteoglycan mediates inductive interaction during plant vascular
RT development.";
RL Nature 429:873-878(2004).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21558309; DOI=10.1093/pcp/pcr060;
RA Kobayashi Y., Motose H., Iwamoto K., Fukuda H.;
RT "Expression and genome-wide analysis of the xylogen-type gene family.";
RL Plant Cell Physiol. 52:1095-1106(2011).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=23893219; DOI=10.1007/s11103-013-0113-5;
RA Edstam M.M., Blomqvist K., Ekloef A., Wennergren U., Edqvist J.;
RT "Coexpression patterns indicate that GPI-anchored non-specific lipid
RT transfer proteins are involved in accumulation of cuticular wax, suberin
RT and sporopollenin.";
RL Plant Mol. Biol. 83:625-649(2013).
CC -!- FUNCTION: Probable lipid transfer protein (By similarity).
CC Proteoglycan-like factor that exhibits xylogen activity consisting in
CC mediating local and inductive cell-cell interactions required for xylem
CC differentiation (PubMed:15215864, PubMed:21558309).
CC {ECO:0000250|UniProtKB:Q9C7F7, ECO:0000269|PubMed:15215864,
CC ECO:0000269|PubMed:21558309}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000255}; Lipid-
CC anchor, GPI-anchor {ECO:0000255}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ZQI8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ZQI8-2; Sequence=VSP_021392;
CC -!- TISSUE SPECIFICITY: Expressed in a vascular-specific manner, mainly in
CC roots, and, to a lower extent, in hypocotyls, seedlings stems and
CC flowers. {ECO:0000269|PubMed:21558309}.
CC -!- DEVELOPMENTAL STAGE: Preferentially expressed in vascular tissues such
CC as the central cylinder, cotyledons of mature embryos and steles in
CC seedlings roots (PubMed:21558309). Accumulates also in emerging root
CC primordia (PubMed:21558309). In aerial parts, a weak expression is
CC observed where new xylem tissues are formed, including the vasculature
CC of young leaves, stem nodes and flower tori (PubMed:21558309).
CC {ECO:0000269|PubMed:21558309}.
CC -!- DISRUPTION PHENOTYPE: No obvious defects in morphology
CC (PubMed:15215864). Plants lacking both XYP1 and XYP2 have morphological
CC defects in vascular development; e.g. discontinuous and thicker veins
CC with the improper interconnection of tracheary elements (TEs)
CC (PubMed:15215864). {ECO:0000269|PubMed:15215864}.
CC -!- MISCELLANEOUS: [Isoform 2]: Has no GPI-anchor. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the plant LTP family. {ECO:0000305}.
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DR EMBL; AC006218; AAD15432.1; -; Genomic_DNA.
DR EMBL; AC006436; AAM15251.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06262.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06263.1; -; Genomic_DNA.
DR EMBL; BT003062; AAO23627.1; -; mRNA.
DR EMBL; AY086354; AAM64422.1; -; mRNA.
DR EMBL; AK227370; BAE99377.1; -; mRNA.
DR PIR; B84511; B84511.
DR RefSeq; NP_179002.1; NM_126958.4. [Q9ZQI8-1]
DR RefSeq; NP_973450.1; NM_201721.2. [Q9ZQI8-2]
DR AlphaFoldDB; Q9ZQI8; -.
DR SMR; Q9ZQI8; -.
DR BioGRID; 1226; 1.
DR STRING; 3702.AT2G13820.1; -.
DR PaxDb; Q9ZQI8; -.
DR PRIDE; Q9ZQI8; -.
DR ProteomicsDB; 251068; -. [Q9ZQI8-1]
DR EnsemblPlants; AT2G13820.1; AT2G13820.1; AT2G13820. [Q9ZQI8-1]
DR EnsemblPlants; AT2G13820.2; AT2G13820.2; AT2G13820. [Q9ZQI8-2]
DR GeneID; 815865; -.
DR Gramene; AT2G13820.1; AT2G13820.1; AT2G13820. [Q9ZQI8-1]
DR Gramene; AT2G13820.2; AT2G13820.2; AT2G13820. [Q9ZQI8-2]
DR KEGG; ath:AT2G13820; -.
DR Araport; AT2G13820; -.
DR TAIR; locus:2043750; AT2G13820.
DR eggNOG; ENOG502S1ZN; Eukaryota.
DR HOGENOM; CLU_089796_5_2_1; -.
DR InParanoid; Q9ZQI8; -.
DR PhylomeDB; Q9ZQI8; -.
DR PRO; PR:Q9ZQI8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZQI8; baseline and differential.
DR Genevisible; Q9ZQI8; AT.
DR GO; GO:0046658; C:anchored component of plasma membrane; HDA:TAIR.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0010089; P:xylem development; IMP:UniProtKB.
DR Gene3D; 1.10.110.10; -; 1.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR InterPro; IPR043325; LTSS.
DR InterPro; IPR000528; Plant_nsLTP.
DR PANTHER; PTHR33044; PTHR33044; 1.
DR Pfam; PF14368; LTP_2; 1.
DR PRINTS; PR00382; LIPIDTRNSFER.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW GPI-anchor; Lipoprotein; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..146
FT /note="Non-specific lipid transfer protein GPI-anchored 11"
FT /id="PRO_0000259454"
FT PROPEP 147..169
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000259455"
FT LIPID 146
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT DISULFID 27..70
FT /evidence="ECO:0000250|UniProtKB:A0A0B4JDK1"
FT DISULFID 37..54
FT /evidence="ECO:0000250|UniProtKB:A0A0B4JDK1"
FT DISULFID 55..95
FT /evidence="ECO:0000250|UniProtKB:A0A0B4JDK1"
FT DISULFID 68..105
FT /evidence="ECO:0000250|UniProtKB:A0A0B4JDK1"
FT VAR_SEQ 120..169
FT /note="LSPTAGAGAPALSSGANAATPVSSPRSSDASLLSVSFAFVIFMALISSFY
FT -> MCYFILKSRD (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_021392"
FT CONFLICT 8
FT /note="M -> V (in Ref. 3; AAO23627 and 5; BAE99377)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 169 AA; 16816 MW; 3822D598E966B96F CRC64;
MAYATILMIF SVVALMSGER AHAAVDCSSL ILNMADCLSF VTSGSTVVKP EGTCCSGLKT
VVRTGPECLC EAFKNSGSLG LTLDLSKAAS LPSVCKVAAP PSARCGLSVS GDPPATAPGL
SPTAGAGAPA LSSGANAATP VSSPRSSDAS LLSVSFAFVI FMALISSFY
