ID   LTMD1_BOVIN             Reviewed;         360 AA.
AC   A3KN46;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=LETM1 domain-containing protein 1 {ECO:0000250|UniProtKB:Q6P1Q0};
GN   Name=LETMD1 {ECO:0000250|UniProtKB:Q6P1Q0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a negative regulator of the p53/TP53 (By
CC       similarity). May play an essential role for mitochondrial structure and
CC       function, and thermogenesis of brown adipocytes (By similarity). May
CC       regulate phagocytosis and inflammatory responses to lipopolysaccharide
CC       in macrophages (By similarity). {ECO:0000250|UniProtKB:Q6P1Q0,
CC       ECO:0000250|UniProtKB:Q924L1}.
CC   -!- SUBUNIT: Interacts with BRI3BP. {ECO:0000250|UniProtKB:Q6P1Q0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q6P1Q0}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q6P1Q0}.
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DR   EMBL; BC133596; AAI33597.1; -; mRNA.
DR   RefSeq; NP_001076899.1; NM_001083430.1.
DR   AlphaFoldDB; A3KN46; -.
DR   SMR; A3KN46; -.
DR   STRING; 9913.ENSBTAP00000038354; -.
DR   PaxDb; A3KN46; -.
DR   GeneID; 514595; -.
DR   KEGG; bta:514595; -.
DR   CTD; 25875; -.
DR   eggNOG; KOG4263; Eukaryota.
DR   InParanoid; A3KN46; -.
DR   OrthoDB; 756155at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   InterPro; IPR011685; LETM1-like.
DR   InterPro; IPR044202; LETM1/MDM38-like.
DR   InterPro; IPR033122; LETM1_RBD.
DR   PANTHER; PTHR14009; PTHR14009; 1.
DR   Pfam; PF07766; LETM1; 1.
DR   PROSITE; PS51758; LETM1_RBD; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..360
FT                   /note="LETM1 domain-containing protein 1"
FT                   /id="PRO_0000310418"
FT   TOPO_DOM        1..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..360
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          186..360
FT                   /note="Letm1 RBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT   REGION          1..110
FT                   /note="Required and sufficient for mitochondrial import"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   360 AA;  41913 MW;  EC738395E9A1AD31 CRC64;
     MALSRVCWAR AALWGSAVPP GLYVVRRLQF VRSGLTWGAP RSSKLHLSPK ADVKSLISYV
     VTKTKVINGK YHRFLGRHFP RFYVPYTIFM KGLQMLWADG KKARRIKTNM WKHNIKFHQL
     PYREMEHLRQ FRRDVTKCLF LGILSIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQIDFL
     DIYHALRKQS HPEILCYLEK VVPLISDAGL QWHMTELCTK MQRGTHPAVH DILALRECFA
     NHPLGMDQLR ALQMKALCRA MLLTPYLPSV LLRHRLKTHT TVIHQLDKAL AKLGVGQLTA
     QEVKSACYLR GLNSTHIAEE RCRTWLGEWL QISCSLKETE LSLLLHNVVL LSINYVGSRR