ID   LTMD1_XENTR             Reviewed;         351 AA.
AC   Q28EM8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=LETM1 domain-containing protein 1 {ECO:0000250|UniProtKB:Q6P1Q0};
GN   Name=letmd1 {ECO:0000250|UniProtKB:Q6P1Q0}; ORFNames=TGas100d16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an essential role for mitochondrial structure and
CC       function. {ECO:0000250|UniProtKB:Q924L1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q6P1Q0}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q6P1Q0}.
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DR   EMBL; CR848166; CAJ83417.1; -; mRNA.
DR   RefSeq; NP_001016022.1; NM_001016022.2.
DR   AlphaFoldDB; Q28EM8; -.
DR   SMR; Q28EM8; -.
DR   PRIDE; Q28EM8; -.
DR   Ensembl; ENSXETT00000063426; ENSXETP00000060095; ENSXETG00000009635.
DR   GeneID; 548776; -.
DR   KEGG; xtr:548776; -.
DR   CTD; 25875; -.
DR   Xenbase; XB-GENE-962658; letmd1.
DR   eggNOG; KOG4263; Eukaryota.
DR   InParanoid; Q28EM8; -.
DR   OrthoDB; 756155at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009635; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q28EM8; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   InterPro; IPR011685; LETM1-like.
DR   InterPro; IPR044202; LETM1/MDM38-like.
DR   InterPro; IPR033122; LETM1_RBD.
DR   PANTHER; PTHR14009; PTHR14009; 1.
DR   Pfam; PF07766; LETM1; 1.
DR   PROSITE; PS51758; LETM1_RBD; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..351
FT                   /note="LETM1 domain-containing protein 1"
FT                   /id="PRO_0000310421"
FT   TOPO_DOM        1..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..351
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          172..351
FT                   /note="Letm1 RBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
SQ   SEQUENCE   351 AA;  41211 MW;  DF91FAAA14C5D780 CRC64;
     MLSGMALCRT RNCRFMMGED GRRMRKCVLL LYQPCHLSTN SKPKSMLSLI ASKAKYANEK
     YEHFLERKFP NFYLLYSTFM KGFRMLMTEA KEVGRIKQRM NHQGIPFHQL PYREMEKLRQ
     FRRDIIKAAP VVIISIPPFA NYLVFVLMYF FPRQLLIRHF WTPKQREEFL DIYHRMRVEA
     YPEILDGLLN AVPKLSERNL RNQMFQLCTQ VQHGTHPQVE NLHAVCTAFS GPPLGMKRLD
     VQQMKALSRV MFLTPHLPAF LLQHRLGSHI CEIQNLDCAL LKLGVNELSE EELKRACYIR
     GLNSTHLSRE DCETWLHCWL QLSSMLKVSE ASLLLHCMVL LSANYLQSIK Q