LTO1_MOUSE
ID LTO1_MOUSE Reviewed; 137 AA.
AC Q8CH62; Q91YY7; Q922P0; Q9D7Y4;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Protein LTO1 homolog {ECO:0000305};
DE AltName: Full=Oral cancer-overexpressed protein 1 homolog;
GN Name=Lto1 {ECO:0000312|MGI:MGI:1919534};
GN Synonyms=Oraov1 {ECO:0000312|MGI:MGI:1919534};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CJ7/129SV;
RA Raabe C.A., Kuryshev V.Y., Brosius J., Skryabin B.V.;
RT "BC1 genomic locus.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Hippocampus, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: The complex LTO1:YAE1 functions as a target specific adapter
CC that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein
CC assembly (CIA) complex machinery. May be required for biogenesis of the
CC large ribosomal subunit and initiation of translation. May play a role
CC in the regulation of proline metabolism and ROS production.
CC {ECO:0000250|UniProtKB:Q8WV07}.
CC -!- SUBUNIT: Forms a complex with YAE1. Interacts with PYCR1 and PYCR2.
CC {ECO:0000250|UniProtKB:Q8WV07}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53846}.
CC -!- SIMILARITY: Belongs to the LTO1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH13564.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB25842.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC38828.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF384675; AAO13812.1; -; Genomic_DNA.
DR EMBL; AK008702; BAB25842.1; ALT_INIT; mRNA.
DR EMBL; AK083244; BAC38828.1; ALT_INIT; mRNA.
DR EMBL; BC006906; AAH06906.1; -; mRNA.
DR EMBL; BC013564; AAH13564.1; ALT_INIT; mRNA.
DR RefSeq; NP_082460.2; NM_028184.3.
DR AlphaFoldDB; Q8CH62; -.
DR STRING; 10090.ENSMUSP00000033388; -.
DR iPTMnet; Q8CH62; -.
DR PhosphoSitePlus; Q8CH62; -.
DR MaxQB; Q8CH62; -.
DR PaxDb; Q8CH62; -.
DR PRIDE; Q8CH62; -.
DR ProteomicsDB; 294079; -.
DR DNASU; 72284; -.
DR GeneID; 72284; -.
DR KEGG; mmu:72284; -.
DR CTD; 220064; -.
DR MGI; MGI:1919534; LTO1.
DR eggNOG; KOG4595; Eukaryota.
DR InParanoid; Q8CH62; -.
DR BioGRID-ORCS; 72284; 30 hits in 109 CRISPR screens.
DR ChiTaRS; LTO1; mouse.
DR PRO; PR:Q8CH62; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CH62; protein.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR InterPro; IPR019191; Essential_protein_Yae1_N.
DR Pfam; PF09811; Yae1_N; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8WV07"
FT CHAIN 2..137
FT /note="Protein LTO1 homolog"
FT /id="PRO_0000058076"
FT REGION 22..58
FT /note="deca-GX3 motif; required for interaction with YAE1
FT and the CIA complex"
FT /evidence="ECO:0000250|UniProtKB:P53846"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8WV07"
FT CONFLICT 73
FT /note="E -> G (in Ref. 2; BAB25842)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 137 AA; 15221 MW; D9ADCA8C35531E95 CRC64;
MAVEQDIFDA VVMADERFHG EGYQEGYEEG SSLGIVEGKR YGMVHGAKIG SEIGCYRGFA
LAWKCLLHSG AGEKDSRKMK VVEALIALLQ DFPYDDPTYE KLHEDLDRIR GKFRQLCSLL
NVQPDFKVTP GGSGLAF
